Univariable and multivariable analysis of progression-free survival
| . | Univariable model . | Multivariable model . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Age, 5-y increase | 1.06 (0.98-1.14) | .14 | — | — |
| Female vs male | 0.96 (0.72-1.29) | .79 | — | — |
| Rai stage at diagnosis, 1 unit increase | 1.35 (1.19-1.53) | <.0001 | 1.16 (1.01-1.34) | .03 |
| Concomitant moAB vs none | 0.82 (0.58-1.16) | .26 | — | — |
| Previously treated vs TN | 3.09 (1.76-5.43) | <.0001 | 2.64 (1.49-4.67) | .0009 |
| ECOG PS score vs 0 | ||||
| 1 | 2.00 (1.47-2.71) | <.0001 | 1.64 (1.19-2.25) | .0023 |
| 2 | 6.73 (3.74-12.12) | <.0001 | 4.01 (2.16-7.42) | <.0001 |
| Hemoglobin, 1 unit increase | 0.85 (0.79-0.90) | <.0001 | 0.93 (0.86-1.00) | .05 |
| Platelets, 50 unit increase | 0.82 (0.74-0.91) | .0004 | — | — |
| WBC count, twofold increase | 1.02 (0.95-1.09) | .58 | — | — |
| LDH ≥ULN vs ≤ULN | 1.74 (1.31-2.31) | .0001 | 1.40 (1.04-1.88) | .03 |
| FISH del(11q) vs no del(11q) | 1.06 (0.80-1.41) | .68 | — | — |
| FISH trisomy 12 vs no trisomy 12 | 1.40 (1.03-1.90) | .03 | — | — |
| FISH del(13q) vs no del(13q) | 1.02 (0.79-1.33) | .87 | — | — |
| FISH del(17p) vs no del(17p) | 1.83 (1.40-2.38) | <.0001 | — | — |
| IGHV unmutated vs mutated | 1.63 (0.93-2.84) | .09 | — | — |
| Karyotypic complexity, 1 unit increase | 1.07 (1.04-1.10) | <.0001 | 1.07 (1.04-1.10) | <.0001 |
| Presence of structural abnormality vs none | 2.32 (1.68-3.20) | <.0001 | — | — |
| . | Univariable model . | Multivariable model . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Age, 5-y increase | 1.06 (0.98-1.14) | .14 | — | — |
| Female vs male | 0.96 (0.72-1.29) | .79 | — | — |
| Rai stage at diagnosis, 1 unit increase | 1.35 (1.19-1.53) | <.0001 | 1.16 (1.01-1.34) | .03 |
| Concomitant moAB vs none | 0.82 (0.58-1.16) | .26 | — | — |
| Previously treated vs TN | 3.09 (1.76-5.43) | <.0001 | 2.64 (1.49-4.67) | .0009 |
| ECOG PS score vs 0 | ||||
| 1 | 2.00 (1.47-2.71) | <.0001 | 1.64 (1.19-2.25) | .0023 |
| 2 | 6.73 (3.74-12.12) | <.0001 | 4.01 (2.16-7.42) | <.0001 |
| Hemoglobin, 1 unit increase | 0.85 (0.79-0.90) | <.0001 | 0.93 (0.86-1.00) | .05 |
| Platelets, 50 unit increase | 0.82 (0.74-0.91) | .0004 | — | — |
| WBC count, twofold increase | 1.02 (0.95-1.09) | .58 | — | — |
| LDH ≥ULN vs ≤ULN | 1.74 (1.31-2.31) | .0001 | 1.40 (1.04-1.88) | .03 |
| FISH del(11q) vs no del(11q) | 1.06 (0.80-1.41) | .68 | — | — |
| FISH trisomy 12 vs no trisomy 12 | 1.40 (1.03-1.90) | .03 | — | — |
| FISH del(13q) vs no del(13q) | 1.02 (0.79-1.33) | .87 | — | — |
| FISH del(17p) vs no del(17p) | 1.83 (1.40-2.38) | <.0001 | — | — |
| IGHV unmutated vs mutated | 1.63 (0.93-2.84) | .09 | — | — |
| Karyotypic complexity, 1 unit increase | 1.07 (1.04-1.10) | <.0001 | 1.07 (1.04-1.10) | <.0001 |
| Presence of structural abnormality vs none | 2.32 (1.68-3.20) | <.0001 | — | — |
del(11q), deletion of 11q; del(13q), deletion of 13q; ULN, upper limit of normal.