Table 5. Average FC for 15 gene-specific... | American Society of Hematology

Table 5.

Average FC for 15 gene-specific signatures in characterized patient groups and uncharacterized individuals

Gene signature	Characterized patient groups (average of 3 patients)			Uncharacterized individual patients
Gene signature	FANC	SBDS	DKC1	4545-TRI	4504-TRI	4592-TRI	4520-SNGL	4633-SNGL	4680-SNGL
FANC_UP	5.60	1.44	0.87	5.87	6.02	1.62	1.52	2.52	8.50
SBDS_UP	1.24	2.73	1.07	1.50	1.66	1.43	1.39	0.73	1.26
DKC1_UP	1.28	1.55	2.89	7.34	1.94	2.43	4.68	3.09	2.34
FANC_DOWN	0.34	0.63	0.71	0.50	0.64	0.62	0.90	0.70	1.35
SBDS_DOWN	0.88	0.42	0.83	0.52	0.59	0.58	0.63	0.76	1.25
DKC1_DOWN	1.27	0.81	0.35	0.53	1.36	0.41	1.72	1.59	2.76

Gene signature	Characterized patient groups (average of 3 patients)			Uncharacterized individual patients
Gene signature	FANC	SBDS	DKC1	4545-TRI	4504-TRI	4592-TRI	4520-SNGL	4633-SNGL	4680-SNGL
FANC_UP	5.60	1.44	0.87	5.87	6.02	1.62	1.52	2.52	8.50
SBDS_UP	1.24	2.73	1.07	1.50	1.66	1.43	1.39	0.73	1.26
DKC1_UP	1.28	1.55	2.89	7.34	1.94	2.43	4.68	3.09	2.34
FANC_DOWN	0.34	0.63	0.71	0.50	0.64	0.62	0.90	0.70	1.35
SBDS_DOWN	0.88	0.42	0.83	0.52	0.59	0.58	0.63	0.76	1.25
DKC1_DOWN	1.27	0.81	0.35	0.53	1.36	0.41	1.72	1.59	2.76

Fold changes either >2 or < 0.5 are considered to be significant.