Table 2.

Extent of exposure to umbralisib

Extent of exposureFL (n = 147)MZL (n = 82)DLBCL/MCL (n = 74)CLL/SLL (n = 43)Other (n = 25)Total (N = 371)
Duration (mo) 
 Mean ± SD 9.8 ± 9.8 10.3 ± 7.0 4.7 ± 8.6 14.7 ± 13.1 3.9 ± 3.6 9.1 ± 9.7 
 Median (min, max) 7.3 (0.1, 75.1) 9.4 (0.2, 24.6) 2.3 (0.1, 65.5) 12.5 (0.7, 55.2) 2.3 (0.2, 14.0) 5.9 (0.1, 75.1) 
Duration, n (%) 
 <3 mo 30 (20.4) 16 (19.5) 45 (60.8) 6 (14.0) 14 (56.0) 111 (29.9) 
 3 to <6 mo 32 (21.8) 16 (19.5) 15 (20.3) 6 (14.0) 7 (28.0) 76 (20.5) 
 6 to <12 mo 44 (29.9) 14 (17.1) 7 (9.5) 9 (20.9) 3 (12.0) 77 (20.8) 
 12 to <18 mo 23 (15.6) 19 (23.2) 4 (5.4) 9 (20.9) 1 (4.0) 56 (15.1) 
 18 to <24 mo 13 (8.8) 16 (19.5) 1 (1.4) 6 (14.0) 36 (9.7) 
 ≥24 mo 5 (3.4) 1 (1.2) 2 (2.7) 7 (16.3) 15 (4.0) 
Extent of exposureFL (n = 147)MZL (n = 82)DLBCL/MCL (n = 74)CLL/SLL (n = 43)Other (n = 25)Total (N = 371)
Duration (mo) 
 Mean ± SD 9.8 ± 9.8 10.3 ± 7.0 4.7 ± 8.6 14.7 ± 13.1 3.9 ± 3.6 9.1 ± 9.7 
 Median (min, max) 7.3 (0.1, 75.1) 9.4 (0.2, 24.6) 2.3 (0.1, 65.5) 12.5 (0.7, 55.2) 2.3 (0.2, 14.0) 5.9 (0.1, 75.1) 
Duration, n (%) 
 <3 mo 30 (20.4) 16 (19.5) 45 (60.8) 6 (14.0) 14 (56.0) 111 (29.9) 
 3 to <6 mo 32 (21.8) 16 (19.5) 15 (20.3) 6 (14.0) 7 (28.0) 76 (20.5) 
 6 to <12 mo 44 (29.9) 14 (17.1) 7 (9.5) 9 (20.9) 3 (12.0) 77 (20.8) 
 12 to <18 mo 23 (15.6) 19 (23.2) 4 (5.4) 9 (20.9) 1 (4.0) 56 (15.1) 
 18 to <24 mo 13 (8.8) 16 (19.5) 1 (1.4) 6 (14.0) 36 (9.7) 
 ≥24 mo 5 (3.4) 1 (1.2) 2 (2.7) 7 (16.3) 15 (4.0) 

Duration of exposure (mo) = (date of last dose – date of first dose + 1)/30.4375.

MCL, mantle cell lymphoma; SD, standard deviation.

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