Evidence for acute and chronic CNS GVHD
| CNS GVHD (n, patient number reported) . | Histology proven, n . | MRI signs, n . | Main finding of the report . | Reference . |
|---|---|---|---|---|
| 7 | 2 (autopsy) | 7 | CNS-related GVHD is a cause of CNS disorders after allo-HSCT and is associated with a poor prognosis. | 28 |
| 1 | 1 (biopsy) | 1 | Although rare, CNS GVHD should be included in the differential diagnosis of CNS lesions in patients after organ transplantation. | 82 |
| 1 | 1 (biopsy) | 1 | Neurologic symptoms improved with methylprednisolone pulse | 83 |
| 1 | 0 | 1 | After intrathecal infusion of methylprednisolone, the clinical symptoms as well as the radiological abnormalities disappeared. | 84 |
| 2 | 1 (biopsy) 1 (autopsy) | 2 | Histology showed profound perivascular lymphocytic infiltrates composed predominantly of T-lymphocytes that were of donor origin. | 85 |
| 1 | 1 (biopsy) | 1 | Histology showed granulomas around small vessels, containing lymphocytes, histiocytes and giant cells. | 86 |
| 1 | 1 (autopsy) | 1 | Angiitis-like syndrome of the CNS neurological manifestation of GVHD. | 87 |
| 1 | 0 | 1 | Steroid treatment caused an immediate improvement in headaches and functional status. | 27 |
| 1 | 1 (biopsy) | 1 | Histologic confirmation of CNS granulomatous angiitis in a patient with GVHD. | 88 |
| 10 | 10 (autopsy) | 2 | Histology showed Iba1+TNF+ cells in the CNS | 25 |
| CNS GVHD (n, patient number reported) . | Histology proven, n . | MRI signs, n . | Main finding of the report . | Reference . |
|---|---|---|---|---|
| 7 | 2 (autopsy) | 7 | CNS-related GVHD is a cause of CNS disorders after allo-HSCT and is associated with a poor prognosis. | 28 |
| 1 | 1 (biopsy) | 1 | Although rare, CNS GVHD should be included in the differential diagnosis of CNS lesions in patients after organ transplantation. | 82 |
| 1 | 1 (biopsy) | 1 | Neurologic symptoms improved with methylprednisolone pulse | 83 |
| 1 | 0 | 1 | After intrathecal infusion of methylprednisolone, the clinical symptoms as well as the radiological abnormalities disappeared. | 84 |
| 2 | 1 (biopsy) 1 (autopsy) | 2 | Histology showed profound perivascular lymphocytic infiltrates composed predominantly of T-lymphocytes that were of donor origin. | 85 |
| 1 | 1 (biopsy) | 1 | Histology showed granulomas around small vessels, containing lymphocytes, histiocytes and giant cells. | 86 |
| 1 | 1 (autopsy) | 1 | Angiitis-like syndrome of the CNS neurological manifestation of GVHD. | 87 |
| 1 | 0 | 1 | Steroid treatment caused an immediate improvement in headaches and functional status. | 27 |
| 1 | 1 (biopsy) | 1 | Histologic confirmation of CNS granulomatous angiitis in a patient with GVHD. | 88 |
| 10 | 10 (autopsy) | 2 | Histology showed Iba1+TNF+ cells in the CNS | 25 |
HSCT, hematopoietic stem cell transplantation; MRI, magnetic resonance imaging.