Effects of calpain inhibitors ALLM, ALLN, and calpastatin peptide on parameters of clot contraction
| . | ALLM (n = 8) . | ALLN (n = 8) . | Calpastatin peptide (n = 3) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No inhibitor . | Inhibitor . | Inhibition, % . | No inhibitor . | Inhibitor . | Inhibition, % . | No inhibitor . | Inhibitor . | Inhibition, % . | |
| Lag time, s | 193 ± 63 | 256 ± 96 | 33* | 201 ± 59 | 261 ± 79 | 30* | 65 ± 31 | 95 ± 17 | 46 |
| Time to 25% contraction, s | 390 ± 122 | 491 ± 152 | 26* | 414 ± 172 | 538 ± 224 | 30* | 150 ± 15 | 175 ± 23 | 17 |
| Time to reach 50% final, s | 476 ± 122 | 523 ± 127 | 10 | 489 ± 159 | 608 ± 222 | 24* | 225 ± 30 | 250 ± 23 | 11 |
| Area under the curve, a.u. | 491 ± 112 | 420 ± 140 | 15* | 475 ± 162 | 396 ± 157 | 17* | 745 ± 21 | 687 ± 25 | 8 |
| Extent of contraction, % | 70 ± 11 | 66 ± 16 | 5 | 72 ± 16 | 69 ± 15 | 3 | 86 ± 3 | 84 ± 1 | 3 |
| . | ALLM (n = 8) . | ALLN (n = 8) . | Calpastatin peptide (n = 3) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No inhibitor . | Inhibitor . | Inhibition, % . | No inhibitor . | Inhibitor . | Inhibition, % . | No inhibitor . | Inhibitor . | Inhibition, % . | |
| Lag time, s | 193 ± 63 | 256 ± 96 | 33* | 201 ± 59 | 261 ± 79 | 30* | 65 ± 31 | 95 ± 17 | 46 |
| Time to 25% contraction, s | 390 ± 122 | 491 ± 152 | 26* | 414 ± 172 | 538 ± 224 | 30* | 150 ± 15 | 175 ± 23 | 17 |
| Time to reach 50% final, s | 476 ± 122 | 523 ± 127 | 10 | 489 ± 159 | 608 ± 222 | 24* | 225 ± 30 | 250 ± 23 | 11 |
| Area under the curve, a.u. | 491 ± 112 | 420 ± 140 | 15* | 475 ± 162 | 396 ± 157 | 17* | 745 ± 21 | 687 ± 25 | 8 |
| Extent of contraction, % | 70 ± 11 | 66 ± 16 | 5 | 72 ± 16 | 69 ± 15 | 3 | 86 ± 3 | 84 ± 1 | 3 |