Number and incidence of patients with CNS involvement in each trial
| Protocol No. . | Mandatory LP . | Years . | No. . | Patients with CNS involvement . | |
|---|---|---|---|---|---|
| No. . | % . | ||||
| E1479 | No | 1980-1982 | 289 | 12 | 4.15 | 
| E3480 | No | 1981-1982 | 39 | 1 | 2.56 | 
| E3483 | Yes | 1984-1988 | 445 | 7 | 1.57 | 
| PC486 | Yes | 1987-1990 | 98 | 0 | |
| E3489 | Yes | 1990-1995 | 752 | 4 | 0.53 | 
| E1490 | Yes | 1990-1992 | 115 | 0 | |
| E3993 | Yes | 1993-1997 | 343 | 4 | 1.17 | 
| E4995 | No | 1996-1997 | 59 | 1 | 1.69 | 
| E3997 | No | 1998-1999 | 35 | 1 | 2.86 | 
| E3999 | No | 2002-2005 | 421 | 0 | |
| E1900 | No | 2002-2008 | 644 | 6 | 0.93 | 
| Protocol No. . | Mandatory LP . | Years . | No. . | Patients with CNS involvement . | |
|---|---|---|---|---|---|
| No. . | % . | ||||
| E1479 | No | 1980-1982 | 289 | 12 | 4.15 | 
| E3480 | No | 1981-1982 | 39 | 1 | 2.56 | 
| E3483 | Yes | 1984-1988 | 445 | 7 | 1.57 | 
| PC486 | Yes | 1987-1990 | 98 | 0 | |
| E3489 | Yes | 1990-1995 | 752 | 4 | 0.53 | 
| E1490 | Yes | 1990-1992 | 115 | 0 | |
| E3993 | Yes | 1993-1997 | 343 | 4 | 1.17 | 
| E4995 | No | 1996-1997 | 59 | 1 | 1.69 | 
| E3997 | No | 1998-1999 | 35 | 1 | 2.86 | 
| E3999 | No | 2002-2005 | 421 | 0 | |
| E1900 | No | 2002-2008 | 644 | 6 | 0.93 |