Table 2. Association of candidate... | American Society of Hematology

Table 2.

Association of candidate variants with stage 2 to 4 gut GVHD disease

Chr	Gene	SNP	Alleles*	Genome	Model	MAF†	Discovery results				Replication results
Chr	Gene	SNP	Alleles*	Genome	Model	MAF†	P	HR	LB	UB	Bf-C	P	HR	LB	UB	Power‡
1	None	rs7517810	C/T	Donor	Recessive	0.25	.004	2.02	1.3	3.1	0.01	.47	1.27	0.7	2.4	36
6	CCND3	rs67289879	C/T	Donor	Recessive	0.21	.001	4.25	2.0	9.0	0.01	.50	0.54	0.1	3.9	13
10	ZMIZ1	rs1250563	G/C	Donor	Allelic	0.31	.0008	1.42	1.2	1.7	0.01	.82	1.03	0.8	1.3	52
10	ZMIZ1	rs1250563	G/C	Donor	Dominant	0.31	.0002	1.70	1.3	2.3	0.01	.34	1.19	0.8	1.7	62
10	IL2RA	rs12722504	GATAA/G	Donor	Recessive	0.26	.001	2.15	1.4	3.3	0.01	.002	0.12	0.02	0.9	3
20	TNFRSF6B	rs6062496	A/G	Donor	Dominant	0.44	.002	0.53	0.4	0.8	0.01	.39	1.28	0.7	2.3	32
2	GCKR	rs1260326	C/T	Recipient	Allelic	0.42	.0002	1.53	1.2	1.9	0.01	.04	1.38	1.0	1.9	56
2	GCKR	rs1260326	C/T	Recipient	Recessive	0.42	.0004	1.96	1.4	2.8	0.01	.02	1.87	1.2	3.0	56
6	HLA-A	NA	Other/HLA-A*0301	Recipient	Dominant	0.15	.004	0.62	0.4	0.9	0.01	.05	1.43	1.0	2.0	55
10	IL2RA	rs12722504	GATAA/G	Recipient	Allelic	0.27	.003	1.40	1.1	1.7	0.01	.01	0.67	0.5	0.9	29
18	None	rs9319943	T/C	Recipient	Allelic	0.18	.003	1.43	1.1	1.8	0.01	.51	1.12	0.8	1.6	32
18	None	rs9319943	T/C	Recipient	Dominant	0.18	.005	1.50	1.1	2.0	0.01	.56	1.12	0.8	1.7	31
21	LOC101927745	rs1736137	A/G	Recipient	Allelic	0.43	.0004	1.42	1.2	1.7	0.01	.42	1.11	0.9	1.5	53
21	LOC101927745	rs1736137	A/G	Recipient	Recessive	0.43	.001	1.72	1.3	2.4	0.01	.76	1.08	0.7	1.7	40

Chr	Gene	SNP	Alleles*	Genome	Model	MAF†	Discovery results				Replication results
Chr	Gene	SNP	Alleles*	Genome	Model	MAF†	P	HR	LB	UB	Bf-C	P	HR	LB	UB	Power‡
1	None	rs7517810	C/T	Donor	Recessive	0.25	.004	2.02	1.3	3.1	0.01	.47	1.27	0.7	2.4	36
6	CCND3	rs67289879	C/T	Donor	Recessive	0.21	.001	4.25	2.0	9.0	0.01	.50	0.54	0.1	3.9	13
10	ZMIZ1	rs1250563	G/C	Donor	Allelic	0.31	.0008	1.42	1.2	1.7	0.01	.82	1.03	0.8	1.3	52
10	ZMIZ1	rs1250563	G/C	Donor	Dominant	0.31	.0002	1.70	1.3	2.3	0.01	.34	1.19	0.8	1.7	62
10	IL2RA	rs12722504	GATAA/G	Donor	Recessive	0.26	.001	2.15	1.4	3.3	0.01	.002	0.12	0.02	0.9	3
20	TNFRSF6B	rs6062496	A/G	Donor	Dominant	0.44	.002	0.53	0.4	0.8	0.01	.39	1.28	0.7	2.3	32
2	GCKR	rs1260326	C/T	Recipient	Allelic	0.42	.0002	1.53	1.2	1.9	0.01	.04	1.38	1.0	1.9	56
2	GCKR	rs1260326	C/T	Recipient	Recessive	0.42	.0004	1.96	1.4	2.8	0.01	.02	1.87	1.2	3.0	56
6	HLA-A	NA	Other/HLA-A*0301	Recipient	Dominant	0.15	.004	0.62	0.4	0.9	0.01	.05	1.43	1.0	2.0	55
10	IL2RA	rs12722504	GATAA/G	Recipient	Allelic	0.27	.003	1.40	1.1	1.7	0.01	.01	0.67	0.5	0.9	29
18	None	rs9319943	T/C	Recipient	Allelic	0.18	.003	1.43	1.1	1.8	0.01	.51	1.12	0.8	1.6	32
18	None	rs9319943	T/C	Recipient	Dominant	0.18	.005	1.50	1.1	2.0	0.01	.56	1.12	0.8	1.7	31
21	LOC101927745	rs1736137	A/G	Recipient	Allelic	0.43	.0004	1.42	1.2	1.7	0.01	.42	1.11	0.9	1.5	53
21	LOC101927745	rs1736137	A/G	Recipient	Recessive	0.43	.001	1.72	1.3	2.4	0.01	.76	1.08	0.7	1.7	40

Bf-C indicates the threshold P value after Bonferroni correction for the number of SNPs in each genome.

Chr, chromosome; LB, lower boundary of the 95% CI; MAF, minor allele frequency; NA, not applicable; UB, upper boundary of the 95% CI.

Plus strand major/minor alleles.

†

MAF in the combined discovery and replication samples used for the evaluation.

‡

Estimates represent the power to detect the discovery effect size at the two-sided Bonferroni-corrected significance level using the estimated replication standard error.

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