Laboratory and echocardiogram findings of patients on HU (N = 60)
| . | Baseline . | Last visit . | P . | ||
|---|---|---|---|---|---|
| Mean ± SD or N . | Range or % . | Mean ± SD or N . | Range or % . | ||
| Age (y) | 10.30 ± 3.40 | 4-17 | 12.70 ± 2.60 | 7-20 | .10 |
| Hb (g/dL) | 8.70 ± 1.10 | 6.90-11.20 | 9.30 ± 0.90 | 7.50-11.10 | .07 |
| MCV (fL) | 76.20 ± 6.80 | 60.30-86.40 | 96.30 ± 14.20 | 66.80-141.10 | .01 |
| Platelet count (K/µL) | 345 ± 87 | 154-544 | 311 ± 95 | 155-490 | .40 |
| HbF (%) | 4.60 ± 6.20 | 1-41 | 14.60 ± 6.90 | 1.60-26 | .002 |
| LVESd z-score | 1.30 ± 0.80 | 0.10-3.30 | 1.10 ± 0.80 | 0.10-2.60 | .45 |
| LVESd z-score ≥2 | 16 | 27 | 7 | 12 | .04 |
| LVEDd z-score | 1.70 ± 1.30 | 0.10-5 | 1.60 ± 1.10 | 0.10-3.60 | .35 |
| LVEDd z-score ≥2 | 21 | 35 | 12 | 20 | .02 |
| LVEDv z-score | 2.20 ± 1.50 | 0.01-6.40 | 1.30 ± 1.10 | 0.10-3.90 | .02 |
| LVEDv z-score ≥2 | 38 | 63 | 16 | 27 | .001 |
| LV mass z-score | 2.50 ± 1.60 | 0.10-5.80 | 1.40 ± 1.20 | 0.10-5.90 | .01 |
| LV mass z-score ≥2 | 34 | 57 | 18 | 30 | .004 |
| LV mass index (g/ht2.7) | 44.80 ± 10.30 | 17.60-71.40 | 42.50 ± 11.30 | 24-69.40 | .47 |
| LVSF (%) | 37 ± 5 | 27-55 | 37 ± 4 | 27-48 | .88 |
| <28% | 3 | 5 | 2 | 3 | .95 |
| LVEF (%) | 60 ± 5 | 47-74 | 61 ± 5 | 48-73 | .73 |
| <55% | 4 | 7 | 3 | 5 | .87 |
| TR (m/s) | 2.30 ± 0.30 | 1.80-3.20 | 2.10 ± 0.20 | 1.70-2.50 | .28 |
| ≥2.5 m/s | 22 | 37 | 7 | 11.5 | .002 |
| . | Baseline . | Last visit . | P . | ||
|---|---|---|---|---|---|
| Mean ± SD or N . | Range or % . | Mean ± SD or N . | Range or % . | ||
| Age (y) | 10.30 ± 3.40 | 4-17 | 12.70 ± 2.60 | 7-20 | .10 |
| Hb (g/dL) | 8.70 ± 1.10 | 6.90-11.20 | 9.30 ± 0.90 | 7.50-11.10 | .07 |
| MCV (fL) | 76.20 ± 6.80 | 60.30-86.40 | 96.30 ± 14.20 | 66.80-141.10 | .01 |
| Platelet count (K/µL) | 345 ± 87 | 154-544 | 311 ± 95 | 155-490 | .40 |
| HbF (%) | 4.60 ± 6.20 | 1-41 | 14.60 ± 6.90 | 1.60-26 | .002 |
| LVESd z-score | 1.30 ± 0.80 | 0.10-3.30 | 1.10 ± 0.80 | 0.10-2.60 | .45 |
| LVESd z-score ≥2 | 16 | 27 | 7 | 12 | .04 |
| LVEDd z-score | 1.70 ± 1.30 | 0.10-5 | 1.60 ± 1.10 | 0.10-3.60 | .35 |
| LVEDd z-score ≥2 | 21 | 35 | 12 | 20 | .02 |
| LVEDv z-score | 2.20 ± 1.50 | 0.01-6.40 | 1.30 ± 1.10 | 0.10-3.90 | .02 |
| LVEDv z-score ≥2 | 38 | 63 | 16 | 27 | .001 |
| LV mass z-score | 2.50 ± 1.60 | 0.10-5.80 | 1.40 ± 1.20 | 0.10-5.90 | .01 |
| LV mass z-score ≥2 | 34 | 57 | 18 | 30 | .004 |
| LV mass index (g/ht2.7) | 44.80 ± 10.30 | 17.60-71.40 | 42.50 ± 11.30 | 24-69.40 | .47 |
| LVSF (%) | 37 ± 5 | 27-55 | 37 ± 4 | 27-48 | .88 |
| <28% | 3 | 5 | 2 | 3 | .95 |
| LVEF (%) | 60 ± 5 | 47-74 | 61 ± 5 | 48-73 | .73 |
| <55% | 4 | 7 | 3 | 5 | .87 |
| TR (m/s) | 2.30 ± 0.30 | 1.80-3.20 | 2.10 ± 0.20 | 1.70-2.50 | .28 |
| ≥2.5 m/s | 22 | 37 | 7 | 11.5 | .002 |
MCV, mean corpuscular volume; SD, standard deviation.