cGVHD characteristics and PROs at enrollment
| Characteristic . | Total (N = 937) . | Alive (n = 604) . | Died (n = 333) . |
|---|---|---|---|
| cGVHD case type | |||
| Incident | 498 (53) | 321 (53) | 177 (53) |
| Prevalent | 439 (47) | 283 (47) | 156 (47) |
| Median time from HCT to cGVHD, mo (range) | 7.5 (1-141) | 7.6 (1-141) | 7.3 (1-58) |
| cGVHD type | |||
| Classic | 320 (34) | 221 (37) | 99 (30) |
| Overlap | 617 (66) | 383 (63) | 234 (70) |
| cGVHD severity | |||
| None | 15 (2) | 9 (2) | 6 (2) |
| Mild | 121 (13) | 82 (14) | 39 (12) |
| Moderate | 459 (49) | 307 (51) | 152 (46) |
| Severe | 342 (37) | 206 (34) | 136 (41) |
| Platelet count × 109/L | |||
| <100 | 137 (15) | 74 (12) | 63 (19) |
| ≥100 | 792 (85) | 524 (88) | 268 (81) |
| Missing | 8 | 6 | 2 |
| Bilirubin, mg/dL | |||
| ≤2 | 884 (96) | 578 (97) | 306 (94) |
| >2 | 37 (4) | 16 (3) | 21 (6) |
| Missing | 16 | 10 | 6 |
| Karnofsky performance score | |||
| <80 | 323 (38) | 176 (32) | 147 (48) |
| ≥80 | 535 (62) | 377 (68) | 158 (52) |
| Missing | 79 | 51 | 28 |
| Skin | |||
| 0-1 | 475 (51) | 312 (52) | 163 (49) |
| 2-3 | 462 (49) | 292 (48) | 170 (51) |
| Fascia | |||
| 0-1 | 864 (92) | 555 (92) | 309 (93) |
| 2-3 | 73 (8) | 49 (8) | 24 (7) |
| Gastrointestinal | |||
| 0-1 | 856 (91) | 557 (92) | 299 (90) |
| 2-3 | 80 (9) | 46 (8) | 34 (10) |
| Missing | 1 | 1 | 0 |
| Esophagus | |||
| 0-1 | 900 (96) | 579 (96) | 321 (96) |
| 2-3 | 37 (4) | 25 (4) | 12 (4) |
| Upper | |||
| 0-1 | 872 (93) | 555 (92) | 317 (95) |
| 2-3 | 65 (7) | 49 (8) | 16 (5) |
| Lower | |||
| 0-1 | 894 (96) | 583 (97) | 311 (94) |
| 2-3 | 41 (4) | 20 (3) | 21 (6) |
| Missing | 2 | 1 | 1 |
| Liver | |||
| 0-1 | 818 (88) | 535 (90) | 283 (86) |
| 2-3 | 108 (12) | 61 (10) | 47 (14) |
| Missing | 11 | 8 | 3 |
| Lung | |||
| 0-1 | 864 (92) | 570 (94) | 294 (88) |
| 2-3 | 73 (8) | 34 (6) | 39 (12) |
| Eye | |||
| 0-1 | 743 (79) | 473 (78) | 270 (81) |
| 2-3 | 193 (21) | 130 (22) | 63 (19) |
| Missing | 1 | 1 | 0 |
| Mouth | |||
| 0-1 | 797 (85) | 519 (86) | 278 (83) |
| 2-3 | 140 (15) | 85 (14) | 55 (17) |
| Joint | |||
| 0-1 | 798 (85) | 509 (84) | 289 (87) |
| 2-3 | 138 (15) | 94 (16) | 44 (13) |
| Missing | 1 | 1 | 0 |
| Genital | |||
| 0-1 | 708 (95) | 436 (95) | 272 (95) |
| 2-3 | 37 (5) | 24 (5) | 13 (5) |
| Missing | 192 | 144 | 48 |
| Median walk test, ft (range) | 484 (62.5-1150) | 500 (62.5-1150) | 450 (144-840) |
| Median grip strength, lbs (range) | 60.6 (2-167) | 62.9 (3.6-167.0) | 57.7 (2-159.7) |
| Median SF-36 score (range) | |||
| Physical component scale | 39 (11-60.7) | 40.4 (11-60.7) | 36.1 (12.1-59.4) |
| Mental component scale | 49.7 (7.1-68.4) | 50.5 (7.1-68.4) | 47.7 (10.6-68.2) |
| Modified HAP-adjusted activity score | 66 (7-94) | 69.0 (20-94) | 59 (7-94) |
| Lee Symptom Scale overall summary score | 21.6 (0-74.4) | 20.3 (0-68.8) | 23.5 (0-74.4) |
| Characteristic . | Total (N = 937) . | Alive (n = 604) . | Died (n = 333) . |
|---|---|---|---|
| cGVHD case type | |||
| Incident | 498 (53) | 321 (53) | 177 (53) |
| Prevalent | 439 (47) | 283 (47) | 156 (47) |
| Median time from HCT to cGVHD, mo (range) | 7.5 (1-141) | 7.6 (1-141) | 7.3 (1-58) |
| cGVHD type | |||
| Classic | 320 (34) | 221 (37) | 99 (30) |
| Overlap | 617 (66) | 383 (63) | 234 (70) |
| cGVHD severity | |||
| None | 15 (2) | 9 (2) | 6 (2) |
| Mild | 121 (13) | 82 (14) | 39 (12) |
| Moderate | 459 (49) | 307 (51) | 152 (46) |
| Severe | 342 (37) | 206 (34) | 136 (41) |
| Platelet count × 109/L | |||
| <100 | 137 (15) | 74 (12) | 63 (19) |
| ≥100 | 792 (85) | 524 (88) | 268 (81) |
| Missing | 8 | 6 | 2 |
| Bilirubin, mg/dL | |||
| ≤2 | 884 (96) | 578 (97) | 306 (94) |
| >2 | 37 (4) | 16 (3) | 21 (6) |
| Missing | 16 | 10 | 6 |
| Karnofsky performance score | |||
| <80 | 323 (38) | 176 (32) | 147 (48) |
| ≥80 | 535 (62) | 377 (68) | 158 (52) |
| Missing | 79 | 51 | 28 |
| Skin | |||
| 0-1 | 475 (51) | 312 (52) | 163 (49) |
| 2-3 | 462 (49) | 292 (48) | 170 (51) |
| Fascia | |||
| 0-1 | 864 (92) | 555 (92) | 309 (93) |
| 2-3 | 73 (8) | 49 (8) | 24 (7) |
| Gastrointestinal | |||
| 0-1 | 856 (91) | 557 (92) | 299 (90) |
| 2-3 | 80 (9) | 46 (8) | 34 (10) |
| Missing | 1 | 1 | 0 |
| Esophagus | |||
| 0-1 | 900 (96) | 579 (96) | 321 (96) |
| 2-3 | 37 (4) | 25 (4) | 12 (4) |
| Upper | |||
| 0-1 | 872 (93) | 555 (92) | 317 (95) |
| 2-3 | 65 (7) | 49 (8) | 16 (5) |
| Lower | |||
| 0-1 | 894 (96) | 583 (97) | 311 (94) |
| 2-3 | 41 (4) | 20 (3) | 21 (6) |
| Missing | 2 | 1 | 1 |
| Liver | |||
| 0-1 | 818 (88) | 535 (90) | 283 (86) |
| 2-3 | 108 (12) | 61 (10) | 47 (14) |
| Missing | 11 | 8 | 3 |
| Lung | |||
| 0-1 | 864 (92) | 570 (94) | 294 (88) |
| 2-3 | 73 (8) | 34 (6) | 39 (12) |
| Eye | |||
| 0-1 | 743 (79) | 473 (78) | 270 (81) |
| 2-3 | 193 (21) | 130 (22) | 63 (19) |
| Missing | 1 | 1 | 0 |
| Mouth | |||
| 0-1 | 797 (85) | 519 (86) | 278 (83) |
| 2-3 | 140 (15) | 85 (14) | 55 (17) |
| Joint | |||
| 0-1 | 798 (85) | 509 (84) | 289 (87) |
| 2-3 | 138 (15) | 94 (16) | 44 (13) |
| Missing | 1 | 1 | 0 |
| Genital | |||
| 0-1 | 708 (95) | 436 (95) | 272 (95) |
| 2-3 | 37 (5) | 24 (5) | 13 (5) |
| Missing | 192 | 144 | 48 |
| Median walk test, ft (range) | 484 (62.5-1150) | 500 (62.5-1150) | 450 (144-840) |
| Median grip strength, lbs (range) | 60.6 (2-167) | 62.9 (3.6-167.0) | 57.7 (2-159.7) |
| Median SF-36 score (range) | |||
| Physical component scale | 39 (11-60.7) | 40.4 (11-60.7) | 36.1 (12.1-59.4) |
| Mental component scale | 49.7 (7.1-68.4) | 50.5 (7.1-68.4) | 47.7 (10.6-68.2) |
| Modified HAP-adjusted activity score | 66 (7-94) | 69.0 (20-94) | 59 (7-94) |
| Lee Symptom Scale overall summary score | 21.6 (0-74.4) | 20.3 (0-68.8) | 23.5 (0-74.4) |
All data are presented as n (%), unless otherwise specified.