Mendelian ratio of mouse pups at birth
| . | Rpl5+/+, n . | Rpl5+/−, n . | Rpl5+/−, % . |
|---|---|---|---|
| Genotyped pups (n = 58) | |||
| Observed | 40 | 18 | 31 |
| Predicted | 29 | 29 | 50 |
| Pups followed up (n = 13) | |||
| Died before weaning, n | 0 | 3 | 60 |
| Survived past weaning, n | 8 | 2 | 40 |
| . | Rpl5+/+, n . | Rpl5+/−, n . | Rpl5+/−, % . |
|---|---|---|---|
| Genotyped pups (n = 58) | |||
| Observed | 40 | 18 | 31 |
| Predicted | 29 | 29 | 50 |
| Pups followed up (n = 13) | |||
| Died before weaning, n | 0 | 3 | 60 |
| Survived past weaning, n | 8 | 2 | 40 |
WT x Rpl5+/− matings were performed, and 14 litters were genotyped (n = 58 pups). The percentage of Rpl5+/− offspring was significantly lower than the Mendelian prediction. χ2 analysis (P = 0.0039). Three litters (n = 13; WT, n = 8; Rpl5+/−, n = 5) were followed up to determine the percentage of newborn pups that died after birth and before weaning. Three of 5 mutant pups (60%) died before weaning: 2 pups on day 1 and 1 pup on day 21.