BBB permeability surface product, cerebral blood flow, cerebral volume, and mean transit time measurements at the time of remission (month 0) and 6 months later (month 6)
| . | Month 0 (N = 7) . | Month 6 (N = 7) . | Mean change(95% CI) . | P* . |
|---|---|---|---|---|
| PS (ml/min/100 g), weighted average (mean [SD]) | ||||
| Right side | 0.92 (0.32) | 0.61 (0.22) | −0.3075 (−0.4428, −0.1722) | .0014 |
| Left side | 0.89 (0.29) | 0.58 (0.23) | −0.3138 (−0.5122, −0.1155) | .0083 |
| Overall† | 0.91 (0.30) | 0.59 (0.22) | −0.3119 (−0.4729, −0.1510) | .0032 |
| CBF (ml/100 g), weighted average (mean [SD]) | ||||
| Right side | 46.8 (4.7) | 43.2 (2.8) | −3.5709 (−8.9584, 1.8165) | .1560 |
| Left side | 47.8 (5.8) | 43.3 (4.9) | −4.5457 (−9.5221, 0.4307) | .0668 |
| Overall† | 48.2 (3.9) | 44.1 (4.0) | −4.0461 (−9.0938, 1.0015) | .0975 |
| CBV (ml/100 g), weighted average (mean [SD]) | ||||
| Right side | 2.84 (0.30) | 2.61 (0.24) | −0.2313 (−0.5939, 0.1314) | .1696 |
| Left side | 2.91 (0.32) | 2.60 (0.38) | −0.3041 (−0.6141, 0.0060) | .0533 |
| Overall† | 2.93 (0.25) | 2.66 (0.32) | −0.2699 (−0.5957, 0.0559) | .0890 |
| MTT (s), weighted average (mean [SD]) | ||||
| Right side | 3.65 (0.12) | 3.62 (0.13) | −0.0275 (0.1801, 0.1250) | .6743 |
| Left side | 3.66 (0.11) | 3.60 (0.14) | −0.0610 (−0.2210, 0.0989) | .3865 |
| Overall† | 3.73 (0.25) | 3.68 (0.19) | −0.0488 (−0.2086, 0.1110) | .4833 |
| . | Month 0 (N = 7) . | Month 6 (N = 7) . | Mean change(95% CI) . | P* . |
|---|---|---|---|---|
| PS (ml/min/100 g), weighted average (mean [SD]) | ||||
| Right side | 0.92 (0.32) | 0.61 (0.22) | −0.3075 (−0.4428, −0.1722) | .0014 |
| Left side | 0.89 (0.29) | 0.58 (0.23) | −0.3138 (−0.5122, −0.1155) | .0083 |
| Overall† | 0.91 (0.30) | 0.59 (0.22) | −0.3119 (−0.4729, −0.1510) | .0032 |
| CBF (ml/100 g), weighted average (mean [SD]) | ||||
| Right side | 46.8 (4.7) | 43.2 (2.8) | −3.5709 (−8.9584, 1.8165) | .1560 |
| Left side | 47.8 (5.8) | 43.3 (4.9) | −4.5457 (−9.5221, 0.4307) | .0668 |
| Overall† | 48.2 (3.9) | 44.1 (4.0) | −4.0461 (−9.0938, 1.0015) | .0975 |
| CBV (ml/100 g), weighted average (mean [SD]) | ||||
| Right side | 2.84 (0.30) | 2.61 (0.24) | −0.2313 (−0.5939, 0.1314) | .1696 |
| Left side | 2.91 (0.32) | 2.60 (0.38) | −0.3041 (−0.6141, 0.0060) | .0533 |
| Overall† | 2.93 (0.25) | 2.66 (0.32) | −0.2699 (−0.5957, 0.0559) | .0890 |
| MTT (s), weighted average (mean [SD]) | ||||
| Right side | 3.65 (0.12) | 3.62 (0.13) | −0.0275 (0.1801, 0.1250) | .6743 |
| Left side | 3.66 (0.11) | 3.60 (0.14) | −0.0610 (−0.2210, 0.0989) | .3865 |
| Overall† | 3.73 (0.25) | 3.68 (0.19) | −0.0488 (−0.2086, 0.1110) | .4833 |
Results are presented as mean (standard deviation). There are no missing values. CBF, cerebral blood flow; CBV, cerebral blood volume; MTT, mean transit time.
A one-sample t test was used to test whether the mean change in each outcome was significantly different from zero.
The overall value is calculated as the weighted average of both the right and left sides.