Table 4.

Stratum-specific likelihood ratios of the PVI score for patients with definite and possible ITP

Definite ITP
PVI scorePVI intervalDefinite ITPNon-ITPProportion with definite ITPStratum-specific likelihood ratios (95% CI)
(n = 104)(n = 339)
PVI ≤ −10 172 0/172 (0.0%) LR = 0 (0-0) 
−10 < PVI ≤−5 45 1/46 (2.2%) SSLR+ = 0.07 (0.01-0.36) 
−5 < PVI ≤ 0 47 0/47 (0.0%) SSLR+ = 0 (0-0) 
0 < PVI ≤ 5 39 6/45 (13.3%) SSLR+ = 0.5 (0.23-1.12) 
5 < PVI ≤ 8 14 8/22 (36.4%) SSLR+ = 1.86 (0.82-4.22) 
8 < PVI ≤ 12 52 20 52/72 (72.2%) SSLR+ = 8.47 (5.34-13.44) 
PVI > 12 37 37/39 (94.9%) SSLR+ = 60.3 (17.08-212.88) 
Definite ITP
PVI scorePVI intervalDefinite ITPNon-ITPProportion with definite ITPStratum-specific likelihood ratios (95% CI)
(n = 104)(n = 339)
PVI ≤ −10 172 0/172 (0.0%) LR = 0 (0-0) 
−10 < PVI ≤−5 45 1/46 (2.2%) SSLR+ = 0.07 (0.01-0.36) 
−5 < PVI ≤ 0 47 0/47 (0.0%) SSLR+ = 0 (0-0) 
0 < PVI ≤ 5 39 6/45 (13.3%) SSLR+ = 0.5 (0.23-1.12) 
5 < PVI ≤ 8 14 8/22 (36.4%) SSLR+ = 1.86 (0.82-4.22) 
8 < PVI ≤ 12 52 20 52/72 (72.2%) SSLR+ = 8.47 (5.34-13.44) 
PVI > 12 37 37/39 (94.9%) SSLR+ = 60.3 (17.08-212.88) 
Possible ITP
PVI scorePVI intervalPossible ITPNon-ITPProportion with possible ITPStratum-specific likelihood ratios (95% CI)
(n = 398)(n = 339)
PVI ≤ −10 57 172 57/229 (24.9%) LR = 0.28 (0.22-0.37) 
−10 < PVI ≤−5 44 45 44/89 (49.4%) SSLR+ = 0.83 (0.57-1.23) 
−5 < PVI ≤ 0 62 47 62/109 (56.9%) SSLR+ = 1.12 (0.79-1.59) 
0 < PVI ≤ 5 60 39 60/99 (60.6%) SSLR+ = 1.31 (0.9-1.9) 
5 < PVI ≤ 8 51 14 51/65 (78.5%) SSLR+ = 3.1 (1.76-5.46) 
8 < PVI ≤ 12 87 20 87/107 (81.3%) SSLR+ = 3.71 (2.34-5.86) 
PVI > 12 37 37/39 (94.9%) SSLR+ = 15.76 (4.42-56.22) 
Possible ITP
PVI scorePVI intervalPossible ITPNon-ITPProportion with possible ITPStratum-specific likelihood ratios (95% CI)
(n = 398)(n = 339)
PVI ≤ −10 57 172 57/229 (24.9%) LR = 0.28 (0.22-0.37) 
−10 < PVI ≤−5 44 45 44/89 (49.4%) SSLR+ = 0.83 (0.57-1.23) 
−5 < PVI ≤ 0 62 47 62/109 (56.9%) SSLR+ = 1.12 (0.79-1.59) 
0 < PVI ≤ 5 60 39 60/99 (60.6%) SSLR+ = 1.31 (0.9-1.9) 
5 < PVI ≤ 8 51 14 51/65 (78.5%) SSLR+ = 3.1 (1.76-5.46) 
8 < PVI ≤ 12 87 20 87/107 (81.3%) SSLR+ = 3.71 (2.34-5.86) 
PVI > 12 37 37/39 (94.9%) SSLR+ = 15.76 (4.42-56.22) 

LR, likelihood ratio for a negative result; SSLR+, stratum-specific likelihood ratio for a positive result within the stratum indicated.

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