Table 1. Cohesin mutation frequency in... | American Society of Hematology

Table 1.

Cohesin mutation frequency in myeloid neoplasms

		Frequency (%)^*
Entity	Total, n	SMC1A	SMC3	STAG2	RAD21	NIPBL	CTCF
De novo AML	2170^8,15,128	2.7	2.7	4.4	2.8	0.57	N/A
NPM1⁺ AML	418¹⁵	1	3	3	7	N/A	1
FLT3⁺ AML	341¹⁵	3	6	3	3	N/A	N/A
t(8;21) AML	254^15,32-34,49	6.3	5.1	1.5	9.9	N/A	N/A
inv(16) AML	189^15,32–34	0.6	0.9	0	0.5	N/A	N/A
MDS	1596^35,38	N/A	1.6	6.3	1.2	0.04	N/A
sAML	93¹³⁰	3	2	14	2	N/A	N/A
AML-MRC	106^8,18	N/A	1	6	3	N/A	N/A
CMML	224^8,131	N/A	N/A	7.4	1.5	N/A	N/A
Pediatric MDS	38³⁹	0	0	0	0	N/A	N/A
Pediatric AML	993¹²⁹	0	1.6	1.2	1.8	1	N/A
DS-AMKL	190^41,42	4.2	2.5	15.7	16.7	4.6	11.7

		Frequency (%)^*
Entity	Total, n	SMC1A	SMC3	STAG2	RAD21	NIPBL	CTCF
De novo AML	2170^8,15,128	2.7	2.7	4.4	2.8	0.57	N/A
NPM1⁺ AML	418¹⁵	1	3	3	7	N/A	1
FLT3⁺ AML	341¹⁵	3	6	3	3	N/A	N/A
t(8;21) AML	254^15,32-34,49	6.3	5.1	1.5	9.9	N/A	N/A
inv(16) AML	189^15,32–34	0.6	0.9	0	0.5	N/A	N/A
MDS	1596^35,38	N/A	1.6	6.3	1.2	0.04	N/A
sAML	93¹³⁰	3	2	14	2	N/A	N/A
AML-MRC	106^8,18	N/A	1	6	3	N/A	N/A
CMML	224^8,131	N/A	N/A	7.4	1.5	N/A	N/A
Pediatric MDS	38³⁹	0	0	0	0	N/A	N/A
Pediatric AML	993¹²⁹	0	1.6	1.2	1.8	1	N/A
DS-AMKL	190^41,42	4.2	2.5	15.7	16.7	4.6	11.7

N/A, data not available. AML-MRC, AML-myelodysplasia-related changes.

Aggregated for multiple cohorts as listed.