Risk of VTE in allogeneic BMT survivors compared with a sibling cohort
| Variable . | Univariable . | Multivariable . | ||||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Cohort | ||||||
| Siblings | 1.00 | |||||
| BMT cohort | 8.21 | (5.29-12.73) | <.0001 | 7.33 | (4.69-11.46) | <.0001 |
| Sex | ||||||
| Female | 1.00 | |||||
| Male | 1.53 | (1.04-2.24) | .029 | |||
| Race/Ethnicity | ||||||
| Non-Hispanic Whites | 1.00 | |||||
| Hispanic | 0.75 | (0.39-1.45) | .394 | |||
| Black | 0.45 | (0.06-3.25) | .431 | |||
| Asian | 1.10 | (0.48-2.53) | .815 | |||
| Other | 0.85 | (0.21-3.45) | .819 | |||
| Education | ||||||
| ≤High school | 1.00 | |||||
| Some college | 1.16 | (0.64-2.08) | .632 | |||
| College graduate | 1.06 | (0.59-1.89) | .848 | |||
| Household income | ||||||
| ≤$50000 | 1.00 | |||||
| $50000-$100000 | 0.78 | (0.47-1.30) | .333 | |||
| >$100000 | 0.96 | (0.61-1.51) | .853 | |||
| Missing | 0.73 | (0.28-1.89) | .519 | |||
| Exercise, yes vs no | ||||||
| Any exercise | 0.89 | (0.59-1.34) | .581 | |||
| Vigorous exercise | 1.14 | (0.78-1.67) | .508 | |||
| Moderate exercise | 0.82 | (0.55-1.22) | .321 | |||
| History of smoking | ||||||
| Yes | 0.28 | (0.07-1.12) | .072 | |||
| Alcohol intake | ||||||
| Yes | 0.85 | (0.58-1.25) | .406 | |||
| Diabetes | ||||||
| Yes | 2.90 | (1.70-4.94) | <.0001 | 1.57 | (0.92-2.66) | .096 |
| Hypertension | ||||||
| Yes | 2.44 | (1.57-3.80) | <.0001 | |||
| BMI | 1.02 | (0.99-1.04) | .267 | |||
| Dyslipidemia | ||||||
| Yes | 2.55 | (1.60-4.06) | <.0001 | |||
| Chronic kidney disease | ||||||
| Yes | 3.28 | (1.51-7.10) | .003 | 2.24 | (1.03-4.87) | .043 |
| Congestive heart failure | ||||||
| Yes | 1.05 | (0.25-4.38) | .946 | |||
| Arrhythmia | ||||||
| Yes | 2.21 | (1.20-4.08) | .011 | |||
| Stroke | ||||||
| Yes | 6.28 | (2.82-13.96) | <.0001 | 4.07 | (1.84-9.01) | .0005 |
| Use of oral contraceptive pills | ||||||
| Yes | 0.76 | (0.31-1.87) | .550 | |||
| Female hormone replacement | ||||||
| Yes | 1.15 | (0.72-1.86) | .559 | |||
| Testosterone replacement | ||||||
| Yes | 1.70 | (0.79-3.67) | .175 | |||
| Variable . | Univariable . | Multivariable . | ||||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Cohort | ||||||
| Siblings | 1.00 | |||||
| BMT cohort | 8.21 | (5.29-12.73) | <.0001 | 7.33 | (4.69-11.46) | <.0001 |
| Sex | ||||||
| Female | 1.00 | |||||
| Male | 1.53 | (1.04-2.24) | .029 | |||
| Race/Ethnicity | ||||||
| Non-Hispanic Whites | 1.00 | |||||
| Hispanic | 0.75 | (0.39-1.45) | .394 | |||
| Black | 0.45 | (0.06-3.25) | .431 | |||
| Asian | 1.10 | (0.48-2.53) | .815 | |||
| Other | 0.85 | (0.21-3.45) | .819 | |||
| Education | ||||||
| ≤High school | 1.00 | |||||
| Some college | 1.16 | (0.64-2.08) | .632 | |||
| College graduate | 1.06 | (0.59-1.89) | .848 | |||
| Household income | ||||||
| ≤$50000 | 1.00 | |||||
| $50000-$100000 | 0.78 | (0.47-1.30) | .333 | |||
| >$100000 | 0.96 | (0.61-1.51) | .853 | |||
| Missing | 0.73 | (0.28-1.89) | .519 | |||
| Exercise, yes vs no | ||||||
| Any exercise | 0.89 | (0.59-1.34) | .581 | |||
| Vigorous exercise | 1.14 | (0.78-1.67) | .508 | |||
| Moderate exercise | 0.82 | (0.55-1.22) | .321 | |||
| History of smoking | ||||||
| Yes | 0.28 | (0.07-1.12) | .072 | |||
| Alcohol intake | ||||||
| Yes | 0.85 | (0.58-1.25) | .406 | |||
| Diabetes | ||||||
| Yes | 2.90 | (1.70-4.94) | <.0001 | 1.57 | (0.92-2.66) | .096 |
| Hypertension | ||||||
| Yes | 2.44 | (1.57-3.80) | <.0001 | |||
| BMI | 1.02 | (0.99-1.04) | .267 | |||
| Dyslipidemia | ||||||
| Yes | 2.55 | (1.60-4.06) | <.0001 | |||
| Chronic kidney disease | ||||||
| Yes | 3.28 | (1.51-7.10) | .003 | 2.24 | (1.03-4.87) | .043 |
| Congestive heart failure | ||||||
| Yes | 1.05 | (0.25-4.38) | .946 | |||
| Arrhythmia | ||||||
| Yes | 2.21 | (1.20-4.08) | .011 | |||
| Stroke | ||||||
| Yes | 6.28 | (2.82-13.96) | <.0001 | 4.07 | (1.84-9.01) | .0005 |
| Use of oral contraceptive pills | ||||||
| Yes | 0.76 | (0.31-1.87) | .550 | |||
| Female hormone replacement | ||||||
| Yes | 1.15 | (0.72-1.86) | .559 | |||
| Testosterone replacement | ||||||
| Yes | 1.70 | (0.79-3.67) | .175 | |||
Bold values in the table body represent statistical significance.