Associations between IL-6 (reflecting inflammation), ERFE (likely reflecting tissue hypoxia), serum hepcidin, and reticulocytosis in patients with tuberculosis (N = 18) at the beginning of intensive phase antituberculosis treatment, and during intensive and continuation phases of antituberculosis treatment
| . | B . | Standard error of B . | Standardized β . |
|---|---|---|---|
| Beginning of intensive phase treatment | |||
| Hepcidin: R2 = 0.438 | |||
| ERFE | −0.347 | 0.167 | −0.357 (P = .046) |
| IL-6 | 0.955 | 0.198 | 0.830 (P < .001) |
| Reticulocytes: R2 = 0.411 | |||
| ERFE | 0.271 | 0.064 | 0.757 (P < .001) |
| IL-6 | −0.319 | 0.076 | −0.750 (P < .001) |
| During intensive phase treatment | |||
| Hepcidin: R2 = 0.329 | |||
| ERFE | −0.323 | 0.143 | −0.315 (P = .028) |
| IL-6 | 0.829 | 0.167 | 0.690 (P < .001) |
| Reticulocytes: R2 = 0.176 | |||
| ERFE | 0.138 | 0.048 | 0.440 (P = .006) |
| IL-6 | −0.014 | 0.056 | −0.038 |
| During continuation phase treatment | |||
| Hepcidin: R2 = 0.280 | |||
| ERFE | −0.471 | 0.109 | −0.540 (P < .001) |
| IL-6 | 0.329 | 0.136 | 0.302 (P = .019) |
| Reticulocytes: R2 = 0.039 | |||
| ERFE | 0.057 | 0.039 | 0.208 |
| IL-6 | −0.022 | .049 | −0.065 |
| . | B . | Standard error of B . | Standardized β . |
|---|---|---|---|
| Beginning of intensive phase treatment | |||
| Hepcidin: R2 = 0.438 | |||
| ERFE | −0.347 | 0.167 | −0.357 (P = .046) |
| IL-6 | 0.955 | 0.198 | 0.830 (P < .001) |
| Reticulocytes: R2 = 0.411 | |||
| ERFE | 0.271 | 0.064 | 0.757 (P < .001) |
| IL-6 | −0.319 | 0.076 | −0.750 (P < .001) |
| During intensive phase treatment | |||
| Hepcidin: R2 = 0.329 | |||
| ERFE | −0.323 | 0.143 | −0.315 (P = .028) |
| IL-6 | 0.829 | 0.167 | 0.690 (P < .001) |
| Reticulocytes: R2 = 0.176 | |||
| ERFE | 0.138 | 0.048 | 0.440 (P = .006) |
| IL-6 | −0.014 | 0.056 | −0.038 |
| During continuation phase treatment | |||
| Hepcidin: R2 = 0.280 | |||
| ERFE | −0.471 | 0.109 | −0.540 (P < .001) |
| IL-6 | 0.329 | 0.136 | 0.302 (P = .019) |
| Reticulocytes: R2 = 0.039 | |||
| ERFE | 0.057 | 0.039 | 0.208 |
| IL-6 | −0.022 | .049 | −0.065 |
Analyzed using linear regression analyses with serum hepcidin and reticulocytes as dependent variables. R2= variance explained by the predictor variables.