Toxicity profile of TIER
AE . | Events . | |
---|---|---|
Grade 3 . | Grade 4 . | |
Hematologic | ||
Anemia | 24 (10) | |
Decreased white blood cell count | 28 (7) | 17 (8) |
Decreased neutrophil count | 39 (14) | 36 (16) |
Decreased lymphocyte count | 29 (8) | 11 (6) |
Decreased platelet count | 40 (12) | 28 (11) |
Febrile neutropenia | 5 (4) | |
Other investigations (cytopenia) | 1 (1) | |
Neurologic or ophthalmologic | ||
Seizure | 2 (2) | 1 (1) |
Confusion | 2 (2) | |
Dysphasia | 2 (2) | |
Agitation | 1 (1) | |
Psychosis | 1 (1) | |
Encephalopathy | 1 (1) | |
Headache | 2 (2) | |
Somnolence | 1 (1) | |
Fatigue | 1 (1) | |
Depression | 1 (1) | |
Left-sided muscle weakness | 1 (1) | |
Syncope | 1 (1) | |
Vasovagal reaction | 1 (1) | |
Ataxia | 1 (1) | |
Nervous system disorders ( drowsiness) | 1 (1) | |
Keratitis | 1 (1) | |
Eye disorders ( right eye vision loss) | 1 (1) | |
Metabolic | ||
Hypophosphatemia | 4 (2) | 2 (1) |
Hypokalemia | 4 (1) | |
Hypomagnesemia | 3 (1) | |
Hyponatremia | 1 (1) | |
Hypoalbuminemia | 2 (1) | |
Hypoglycemia | 1 (1) | |
Infective | ||
Bronchial infection | 1 (1) | |
Infections and infestations ( lower respiratory tract infection) | 1 (1) | |
Upper respiratory infection | 1 (1) | |
General disorders and administration site conditions ( influenza) | 1 (1) | |
Urinary tract infection | 1 (1) | |
Infections and infestations | ||
Neutropenic sepsis | 1 (1) | |
Other infection | 1 (1) | |
Gastrointestinal | ||
Dysphagia | 2 (2) | |
Diarrhea | 1 (1) | |
Oral mucositis | 1 (1) | |
Other | ||
Hypertension | 1 (1) | |
Urinary incontinence | 1 (1) | |
Increased lipase | 1 (1) | |
Increased alanine aminotransferase | 1 (1) |
AE . | Events . | |
---|---|---|
Grade 3 . | Grade 4 . | |
Hematologic | ||
Anemia | 24 (10) | |
Decreased white blood cell count | 28 (7) | 17 (8) |
Decreased neutrophil count | 39 (14) | 36 (16) |
Decreased lymphocyte count | 29 (8) | 11 (6) |
Decreased platelet count | 40 (12) | 28 (11) |
Febrile neutropenia | 5 (4) | |
Other investigations (cytopenia) | 1 (1) | |
Neurologic or ophthalmologic | ||
Seizure | 2 (2) | 1 (1) |
Confusion | 2 (2) | |
Dysphasia | 2 (2) | |
Agitation | 1 (1) | |
Psychosis | 1 (1) | |
Encephalopathy | 1 (1) | |
Headache | 2 (2) | |
Somnolence | 1 (1) | |
Fatigue | 1 (1) | |
Depression | 1 (1) | |
Left-sided muscle weakness | 1 (1) | |
Syncope | 1 (1) | |
Vasovagal reaction | 1 (1) | |
Ataxia | 1 (1) | |
Nervous system disorders ( drowsiness) | 1 (1) | |
Keratitis | 1 (1) | |
Eye disorders ( right eye vision loss) | 1 (1) | |
Metabolic | ||
Hypophosphatemia | 4 (2) | 2 (1) |
Hypokalemia | 4 (1) | |
Hypomagnesemia | 3 (1) | |
Hyponatremia | 1 (1) | |
Hypoalbuminemia | 2 (1) | |
Hypoglycemia | 1 (1) | |
Infective | ||
Bronchial infection | 1 (1) | |
Infections and infestations ( lower respiratory tract infection) | 1 (1) | |
Upper respiratory infection | 1 (1) | |
General disorders and administration site conditions ( influenza) | 1 (1) | |
Urinary tract infection | 1 (1) | |
Infections and infestations | ||
Neutropenic sepsis | 1 (1) | |
Other infection | 1 (1) | |
Gastrointestinal | ||
Dysphagia | 2 (2) | |
Diarrhea | 1 (1) | |
Oral mucositis | 1 (1) | |
Other | ||
Hypertension | 1 (1) | |
Urinary incontinence | 1 (1) | |
Increased lipase | 1 (1) | |
Increased alanine aminotransferase | 1 (1) |
All data are n (%). All grade 3 and 4 AEs are listed. Terms from Common Terminology Criteria for Adverse Events version 4.0 are arranged into clinically related groups. Total number of patients, 36.