Toxicity profile of TIER
| AE . | Events . | |
|---|---|---|
| Grade 3 . | Grade 4 . | |
| Hematologic | ||
| Anemia | 24 (10) | |
| Decreased white blood cell count | 28 (7) | 17 (8) |
| Decreased neutrophil count | 39 (14) | 36 (16) |
| Decreased lymphocyte count | 29 (8) | 11 (6) |
| Decreased platelet count | 40 (12) | 28 (11) |
| Febrile neutropenia | 5 (4) | |
| Other investigations (cytopenia) | 1 (1) | |
| Neurologic or ophthalmologic | ||
| Seizure | 2 (2) | 1 (1) |
| Confusion | 2 (2) | |
| Dysphasia | 2 (2) | |
| Agitation | 1 (1) | |
| Psychosis | 1 (1) | |
| Encephalopathy | 1 (1) | |
| Headache | 2 (2) | |
| Somnolence | 1 (1) | |
| Fatigue | 1 (1) | |
| Depression | 1 (1) | |
| Left-sided muscle weakness | 1 (1) | |
| Syncope | 1 (1) | |
| Vasovagal reaction | 1 (1) | |
| Ataxia | 1 (1) | |
| Nervous system disorders ( drowsiness) | 1 (1) | |
| Keratitis | 1 (1) | |
| Eye disorders ( right eye vision loss) | 1 (1) | |
| Metabolic | ||
| Hypophosphatemia | 4 (2) | 2 (1) |
| Hypokalemia | 4 (1) | |
| Hypomagnesemia | 3 (1) | |
| Hyponatremia | 1 (1) | |
| Hypoalbuminemia | 2 (1) | |
| Hypoglycemia | 1 (1) | |
| Infective | ||
| Bronchial infection | 1 (1) | |
| Infections and infestations ( lower respiratory tract infection) | 1 (1) | |
| Upper respiratory infection | 1 (1) | |
| General disorders and administration site conditions ( influenza) | 1 (1) | |
| Urinary tract infection | 1 (1) | |
| Infections and infestations | ||
| Neutropenic sepsis | 1 (1) | |
| Other infection | 1 (1) | |
| Gastrointestinal | ||
| Dysphagia | 2 (2) | |
| Diarrhea | 1 (1) | |
| Oral mucositis | 1 (1) | |
| Other | ||
| Hypertension | 1 (1) | |
| Urinary incontinence | 1 (1) | |
| Increased lipase | 1 (1) | |
| Increased alanine aminotransferase | 1 (1) | |
| AE . | Events . | |
|---|---|---|
| Grade 3 . | Grade 4 . | |
| Hematologic | ||
| Anemia | 24 (10) | |
| Decreased white blood cell count | 28 (7) | 17 (8) |
| Decreased neutrophil count | 39 (14) | 36 (16) |
| Decreased lymphocyte count | 29 (8) | 11 (6) |
| Decreased platelet count | 40 (12) | 28 (11) |
| Febrile neutropenia | 5 (4) | |
| Other investigations (cytopenia) | 1 (1) | |
| Neurologic or ophthalmologic | ||
| Seizure | 2 (2) | 1 (1) |
| Confusion | 2 (2) | |
| Dysphasia | 2 (2) | |
| Agitation | 1 (1) | |
| Psychosis | 1 (1) | |
| Encephalopathy | 1 (1) | |
| Headache | 2 (2) | |
| Somnolence | 1 (1) | |
| Fatigue | 1 (1) | |
| Depression | 1 (1) | |
| Left-sided muscle weakness | 1 (1) | |
| Syncope | 1 (1) | |
| Vasovagal reaction | 1 (1) | |
| Ataxia | 1 (1) | |
| Nervous system disorders ( drowsiness) | 1 (1) | |
| Keratitis | 1 (1) | |
| Eye disorders ( right eye vision loss) | 1 (1) | |
| Metabolic | ||
| Hypophosphatemia | 4 (2) | 2 (1) |
| Hypokalemia | 4 (1) | |
| Hypomagnesemia | 3 (1) | |
| Hyponatremia | 1 (1) | |
| Hypoalbuminemia | 2 (1) | |
| Hypoglycemia | 1 (1) | |
| Infective | ||
| Bronchial infection | 1 (1) | |
| Infections and infestations ( lower respiratory tract infection) | 1 (1) | |
| Upper respiratory infection | 1 (1) | |
| General disorders and administration site conditions ( influenza) | 1 (1) | |
| Urinary tract infection | 1 (1) | |
| Infections and infestations | ||
| Neutropenic sepsis | 1 (1) | |
| Other infection | 1 (1) | |
| Gastrointestinal | ||
| Dysphagia | 2 (2) | |
| Diarrhea | 1 (1) | |
| Oral mucositis | 1 (1) | |
| Other | ||
| Hypertension | 1 (1) | |
| Urinary incontinence | 1 (1) | |
| Increased lipase | 1 (1) | |
| Increased alanine aminotransferase | 1 (1) | |
All data are n (%). All grade 3 and 4 AEs are listed. Terms from Common Terminology Criteria for Adverse Events version 4.0 are arranged into clinically related groups. Total number of patients, 36.