Clinical and hematologic data of the total group of patients with CIN and comparison between the nonclonal and clonal (CCUS) subgroups categorized on the basis of mutation status
| Variable . | Total patients with CIN . | Nonclonal patients with CIN . | Clonal CIN (CCUS) patients . | P* . |
|---|---|---|---|---|
| No. of patients | 185 | 164 | 21 | |
| Age, y | 57 ± 17 | 56 ± 17 | 67 ± 14 | .0052 |
| Median, range | (59, 18-89) | (58, 18-89) | (68, 44-87) | |
| Sex (female/male) | 146/39 | 129/35 | 17/4 | NS |
| Disease duration, mo† | 171 ± 100 | 170 ± 98 | 176 ± 120 | NS |
| Median, range | (168, 12-408) | (168, 12-408) | (144, 12-396) | |
| WBC count, ×109/L | 3.46 ± 0.60 | 3.48 ± 0.62 | 3.30 ± 0.46 | NS |
| Median, range | (3.50, 1.90-5.70) | (3.50, 1.90-5.70) | (3.30, 2.10-4.00) | |
| ANC, ×109/L | 1.39 ± 0.42 | 1.39 ± 0.43 | 1.36 ± 0.37 | NS |
| Median, range | (1.60, 0.20-1.70) | (1.60, 0.20-1.70) | (1.50, 0.50-1.70) | |
| Monocyte count, ×109/L | 0.33 ± 0.13 | 0.34 ± 0.14 | 0.33 ± 0.12 | NS |
| Median, range | (0.30, 0.10-0.70) | (0.30, 0.10-0.70) | (0.30, 0.20-0.60) | |
| Lymphocyte count, ×109/L | 1.62 ± 0.45 | 1.63 ± 0.45 | 1.54 ± 0.39 | NS |
| Median, range | (1.60, 0.70-3.25) | (1.60, 0.70-3.25) | (1.60, 0.80-2.30) | |
| Hgb, g/dL | 13.31 ± 0.96 | 13.29 ± 0.97 | 13.45 ± 0.89 | NS |
| Median, range | (13.20, 10.60 – 16.20) | (13.20, 10.60 – 16.20) | (13.40, 11.30 – 15.80) | |
| MCV, fL | 88.13 ± 5.56 | 88.31 ± 5.41 | 86.74 ± 6.61 | NS |
| Median, range | (89.0, 65.00-97.70) | (89.00, 65.00-97.70) | (88.90, 66.90-93.30) | |
| Platelet count, ×109/L | 222 ± 47 | 224 ± 47 | 197 ± 42 | .011 |
| Median, range | (221, 150-336) | (226, 150-336) | (185, 150-265) |
| Variable . | Total patients with CIN . | Nonclonal patients with CIN . | Clonal CIN (CCUS) patients . | P* . |
|---|---|---|---|---|
| No. of patients | 185 | 164 | 21 | |
| Age, y | 57 ± 17 | 56 ± 17 | 67 ± 14 | .0052 |
| Median, range | (59, 18-89) | (58, 18-89) | (68, 44-87) | |
| Sex (female/male) | 146/39 | 129/35 | 17/4 | NS |
| Disease duration, mo† | 171 ± 100 | 170 ± 98 | 176 ± 120 | NS |
| Median, range | (168, 12-408) | (168, 12-408) | (144, 12-396) | |
| WBC count, ×109/L | 3.46 ± 0.60 | 3.48 ± 0.62 | 3.30 ± 0.46 | NS |
| Median, range | (3.50, 1.90-5.70) | (3.50, 1.90-5.70) | (3.30, 2.10-4.00) | |
| ANC, ×109/L | 1.39 ± 0.42 | 1.39 ± 0.43 | 1.36 ± 0.37 | NS |
| Median, range | (1.60, 0.20-1.70) | (1.60, 0.20-1.70) | (1.50, 0.50-1.70) | |
| Monocyte count, ×109/L | 0.33 ± 0.13 | 0.34 ± 0.14 | 0.33 ± 0.12 | NS |
| Median, range | (0.30, 0.10-0.70) | (0.30, 0.10-0.70) | (0.30, 0.20-0.60) | |
| Lymphocyte count, ×109/L | 1.62 ± 0.45 | 1.63 ± 0.45 | 1.54 ± 0.39 | NS |
| Median, range | (1.60, 0.70-3.25) | (1.60, 0.70-3.25) | (1.60, 0.80-2.30) | |
| Hgb, g/dL | 13.31 ± 0.96 | 13.29 ± 0.97 | 13.45 ± 0.89 | NS |
| Median, range | (13.20, 10.60 – 16.20) | (13.20, 10.60 – 16.20) | (13.40, 11.30 – 15.80) | |
| MCV, fL | 88.13 ± 5.56 | 88.31 ± 5.41 | 86.74 ± 6.61 | NS |
| Median, range | (89.0, 65.00-97.70) | (89.00, 65.00-97.70) | (88.90, 66.90-93.30) | |
| Platelet count, ×109/L | 222 ± 47 | 224 ± 47 | 197 ± 42 | .011 |
| Median, range | (221, 150-336) | (226, 150-336) | (185, 150-265) |
Grouped data are expressed as means ± 1 SD.
ANC, absolute neutrophil count; Hgb, hemoglobin; MCV, mean corpuscular volume; NS, nonsignificant; WBC, white blood cell.
P values indicate the statistical difference for the comparison between the nonclonal and clonal CIN using the Student t test.
Time from the identification of neutropenia until the last follow-up or disease transformation.