Univariate and multivariable analyses of prognostic factors associated with PFS and OS
| Variable . | Univariate analysis . | Multivariable analysis . | ||
|---|---|---|---|---|
| HR [95% CI] . | P . | HR [95% CI] . | P . | |
| PFS | ||||
| Treatment (ref = R-ACVBP) | ||||
| R-CHOP14 | 0.90 [0.40-2.03] | .798 | 0.26 [0.06-1.12] | .071 |
| R-CHOP21 | 2.37 [1.20-4.67] | .012 | 1.06 [0.41-2.76] | .897 |
| LDH >ULN | 0.83 [0.38-1.79] | .63 | 1.04 [0.34-3.14] | .949 |
| IPI 3-5 | 1.48 [0.77-2.83] | .24 | 1.33 [0.56-3.16] | .511 |
| Presence of B symptoms | 1.91 [1.05-3.47] | .034 | 1.66 [0.76-3.60] | .200 |
| TMTV ≥360 cm3 | 2.18 [1.05-4.53] | .037 | 2.13 [0.89-5.10] | .088 |
| Bulky disease ≥10 cm | 1.76 [0.92-3.39] | .087 | 1.12 [0.48-2.64] | .795 |
| Pericardial or pleural effusion | 1.09 [0.59-1.99] | .788 | 1.10 [0.51-2.39] | .809 |
| OS | ||||
| Treatment (ref = R-ACVBP) | ||||
| R-CHOP14 | Infinite | Infinite | ||
| R-CHOP21 | 1.95 [0.82-4.66] | .131 | 0.76 [0.21-2.83] | .685 |
| LDH >ULN | 1.13 [0.33-3.86] | .84 | 2.19 [0.28-17.2] | .454 |
| IPI 3-5 | 2.73 [1.13-6.58] | .025 | 1.72 [0.58-5.07] | .326 |
| Presence of B symptoms | 2.61 [1.12-6.11] | .027 | 2.66 [0.87-8.10] | .086 |
| TMTV ≥360 cm3 | 4.26 [1.50-12.11] | .007 | 5.68 [1.61-20.06] | .007 |
| Bulky disease ≥10 cm | 1.13 [0.48-2.66] | .773 | 0.59 [0.20-1.74] | .339 |
| Pericardial or pleural effusion | 1.08 [0.46-2.54] | .86 | 1.07 [0.38-3.02] | .903 |
| Variable . | Univariate analysis . | Multivariable analysis . | ||
|---|---|---|---|---|
| HR [95% CI] . | P . | HR [95% CI] . | P . | |
| PFS | ||||
| Treatment (ref = R-ACVBP) | ||||
| R-CHOP14 | 0.90 [0.40-2.03] | .798 | 0.26 [0.06-1.12] | .071 |
| R-CHOP21 | 2.37 [1.20-4.67] | .012 | 1.06 [0.41-2.76] | .897 |
| LDH >ULN | 0.83 [0.38-1.79] | .63 | 1.04 [0.34-3.14] | .949 |
| IPI 3-5 | 1.48 [0.77-2.83] | .24 | 1.33 [0.56-3.16] | .511 |
| Presence of B symptoms | 1.91 [1.05-3.47] | .034 | 1.66 [0.76-3.60] | .200 |
| TMTV ≥360 cm3 | 2.18 [1.05-4.53] | .037 | 2.13 [0.89-5.10] | .088 |
| Bulky disease ≥10 cm | 1.76 [0.92-3.39] | .087 | 1.12 [0.48-2.64] | .795 |
| Pericardial or pleural effusion | 1.09 [0.59-1.99] | .788 | 1.10 [0.51-2.39] | .809 |
| OS | ||||
| Treatment (ref = R-ACVBP) | ||||
| R-CHOP14 | Infinite | Infinite | ||
| R-CHOP21 | 1.95 [0.82-4.66] | .131 | 0.76 [0.21-2.83] | .685 |
| LDH >ULN | 1.13 [0.33-3.86] | .84 | 2.19 [0.28-17.2] | .454 |
| IPI 3-5 | 2.73 [1.13-6.58] | .025 | 1.72 [0.58-5.07] | .326 |
| Presence of B symptoms | 2.61 [1.12-6.11] | .027 | 2.66 [0.87-8.10] | .086 |
| TMTV ≥360 cm3 | 4.26 [1.50-12.11] | .007 | 5.68 [1.61-20.06] | .007 |
| Bulky disease ≥10 cm | 1.13 [0.48-2.66] | .773 | 0.59 [0.20-1.74] | .339 |
| Pericardial or pleural effusion | 1.08 [0.46-2.54] | .86 | 1.07 [0.38-3.02] | .903 |
Regarding OS, no deaths were observed in the R-CHOP14 group, and thus the HR is infinite. Bold characters indicate that the P value is inferior to .05. LDH, lactate dehydrogenase; ref, reference; ULN, upper limit of normal laboratory value.