Analysis of survival by baseline patient characteristics
| . | PFS . | OS . | ||||
|---|---|---|---|---|---|---|
| Patient characteristic . | HR . | 95% CI . | P* . | HR . | 95% CI . | P* . |
| Male sex | 1.19 | 0.78-1.80 | .42 | 1.44 | 0.76-2.71 | .26 |
| Age 60-69 vs ≥70 y | 0.81 | 0.53-1.23 | .31 | 0.59 | 0.29-1.06 | .07 |
| Advanced stage | 1.75 | 1.14-2.70 | .02 | 1.75 | 0.92-3.33 | .12 |
| Impaired ADLs/instrumental ADLs | 2.11 | 1.03-4.30 | .006 | 3.58 | 1.42-8.92 | <.0001 |
| Geriatric syndrome | 1.24 | 0.70-2.18 | .44 | 2.21 | 0.88-5.54 | .03 |
| CIRS-G total <10 vs ≥10 | 1.05 | 0.62-1.77 | .87 | 2.11 | 0.92-4.85 | .03 |
| Multivariable Cox proportional hazards model (backward elimination) | ||||||
| Impaired ADLs/instrumental ADLs | 2.13 | 1.23-3.69 | .007 | 2.52 | 1.13-5.58 | .02 |
| . | PFS . | OS . | ||||
|---|---|---|---|---|---|---|
| Patient characteristic . | HR . | 95% CI . | P* . | HR . | 95% CI . | P* . |
| Male sex | 1.19 | 0.78-1.80 | .42 | 1.44 | 0.76-2.71 | .26 |
| Age 60-69 vs ≥70 y | 0.81 | 0.53-1.23 | .31 | 0.59 | 0.29-1.06 | .07 |
| Advanced stage | 1.75 | 1.14-2.70 | .02 | 1.75 | 0.92-3.33 | .12 |
| Impaired ADLs/instrumental ADLs | 2.11 | 1.03-4.30 | .006 | 3.58 | 1.42-8.92 | <.0001 |
| Geriatric syndrome | 1.24 | 0.70-2.18 | .44 | 2.21 | 0.88-5.54 | .03 |
| CIRS-G total <10 vs ≥10 | 1.05 | 0.62-1.77 | .87 | 2.11 | 0.92-4.85 | .03 |
| Multivariable Cox proportional hazards model (backward elimination) | ||||||
| Impaired ADLs/instrumental ADLs | 2.13 | 1.23-3.69 | .007 | 2.52 | 1.13-5.58 | .02 |
All P values are 2 sided.