Characteristics of patients treated with intensive chemotherapy
| . | Total cohort . | SF-mutated patients . |
|---|---|---|
| Age, median (range), y | 54 (17.8-85.9) | 60 (18.0-83.8) |
| Sex | ||
| Male | 664 (54.3) | 109 (68.1) |
| Female | 559 (45.7) | 51 (31.9) |
| Entity | ||
| de novo AML | 1047 (85.6) | 126 (78.7) |
| sAML | 61 (5.0) | 16 (10.0) |
| MDS | 72 (5.9) | 15 (9.4) |
| tAML | 43 (3.5) | 3 (1.9) |
| WBC count, × 109/L | ||
| ≤100 | 1047 (85.6) | 142 (88.7) |
| >100 | 110 (9.0) | 10 (6.3) |
| Missing data | 66 (5.4) | 8 (5.0) |
| ELN classification | ||
| Favorable | 483 (39.4) | 33 (20.6) |
| Intermediate | 337 (27.6) | 33 (20.6) |
| Adverse | 403 (33.0) | 94 (58.8) |
| Induction response | ||
| CR | 1045 (85.4) | 122 |
| Partial response | 35 (2.9) | 8 (5.0) |
| Early death | 65 (5.3) | 17 (10.6) |
| Refractory disease | 62 (5.1) | 13 (8.1) |
| Missing data | 16 (1.3) | — |
| Disease course | ||
| Relapse | 411 (33.6) | 52 (32.5) |
| Death | 629 (51.4) | 107 (66.9) |
| Stem cell transplantation | ||
| None | 541 (44.2) | 90 (56.3) |
| Autologous transplantation | 122 (10.0) | 9 (5.6) |
| Allogeneic transplantation | 560 (45.8) | 61 (38.1) |
| . | Total cohort . | SF-mutated patients . |
|---|---|---|
| Age, median (range), y | 54 (17.8-85.9) | 60 (18.0-83.8) |
| Sex | ||
| Male | 664 (54.3) | 109 (68.1) |
| Female | 559 (45.7) | 51 (31.9) |
| Entity | ||
| de novo AML | 1047 (85.6) | 126 (78.7) |
| sAML | 61 (5.0) | 16 (10.0) |
| MDS | 72 (5.9) | 15 (9.4) |
| tAML | 43 (3.5) | 3 (1.9) |
| WBC count, × 109/L | ||
| ≤100 | 1047 (85.6) | 142 (88.7) |
| >100 | 110 (9.0) | 10 (6.3) |
| Missing data | 66 (5.4) | 8 (5.0) |
| ELN classification | ||
| Favorable | 483 (39.4) | 33 (20.6) |
| Intermediate | 337 (27.6) | 33 (20.6) |
| Adverse | 403 (33.0) | 94 (58.8) |
| Induction response | ||
| CR | 1045 (85.4) | 122 |
| Partial response | 35 (2.9) | 8 (5.0) |
| Early death | 65 (5.3) | 17 (10.6) |
| Refractory disease | 62 (5.1) | 13 (8.1) |
| Missing data | 16 (1.3) | — |
| Disease course | ||
| Relapse | 411 (33.6) | 52 (32.5) |
| Death | 629 (51.4) | 107 (66.9) |
| Stem cell transplantation | ||
| None | 541 (44.2) | 90 (56.3) |
| Autologous transplantation | 122 (10.0) | 9 (5.6) |
| Allogeneic transplantation | 560 (45.8) | 61 (38.1) |
All data are n (%), unless otherwise noted. — denotes no missing data for induction of response of patients with SF mutations.