Table 1.

Durability of benefit in deep responders: PFS and duration of response

Continuous Ven (n = 14)Limited-duration Ven* (n = 19)All deep responders (n = 33)
Median time on Ven, y (range) 5.6 (2.4-6.6) 1.4 (0.4-4.2) 3.1 (0.5-6.6) 
PFS 
 Median, y (95% CI) 6.6 (4.6-6.6) 6.5 (3.6-6.5) 6.5 (5.5-6.6) 
 3-y estimate (95% CI) 92.9% (59.1-99.0) 87.1% (57.3-96.6) 89.9% (71.8-96.6) 
 5-y estimate (95% CI) 78.6% (47.2-92.5) 79.8% (49.4-93.0) 79.1% (59.1-90.0) 
Duration of response 
 Median, y (95% CI) 6.3 (4.4-6.3) 6.2 (3.4-6.2) 6.2 (5.4-6.3) 
 3-y estimate (95% CI) 85.7% (53.9-96.2) 86.7% (56.4-96.5) 86.2% (67.2-94.6) 
 5-y estimate (95% CI) 70.7% (39.4-87.9) 79.4% (48.8-92.9) 73.9% (52.4-86.8) 
Continuous Ven (n = 14)Limited-duration Ven* (n = 19)All deep responders (n = 33)
Median time on Ven, y (range) 5.6 (2.4-6.6) 1.4 (0.4-4.2) 3.1 (0.5-6.6) 
PFS 
 Median, y (95% CI) 6.6 (4.6-6.6) 6.5 (3.6-6.5) 6.5 (5.5-6.6) 
 3-y estimate (95% CI) 92.9% (59.1-99.0) 87.1% (57.3-96.6) 89.9% (71.8-96.6) 
 5-y estimate (95% CI) 78.6% (47.2-92.5) 79.8% (49.4-93.0) 79.1% (59.1-90.0) 
Duration of response 
 Median, y (95% CI) 6.3 (4.4-6.3) 6.2 (3.4-6.2) 6.2 (5.4-6.3) 
 3-y estimate (95% CI) 85.7% (53.9-96.2) 86.7% (56.4-96.5) 86.2% (67.2-94.6) 
 5-y estimate (95% CI) 70.7% (39.4-87.9) 79.4% (48.8-92.9) 73.9% (52.4-86.8) 
*

Includes 1 patient who was on continuous Ven for 4.2 y and recently discontinued therapy because of good response.

DOR and PFS were derived using the Kaplan-Meier methodology.

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