AAV vector molar mass and composition
| AAV sample . | Vector Mw, MDa . | Capsid Mw, MDa . | Nucleic acid Mw, kDa . |
|---|---|---|---|
| hFIX-Padua | 4.53 ± 0.04 | 3.86 ± 0.01 | 666 ± 36 |
| An96 | 4.42 ± 0.08 | 3.81 ± 0.05 | 609 ± 32 |
| An96-Padua | 4.62 ± 0.08 | 3.74 ± 0.05 | 914 ± 390 |
| AAV sample . | Vector Mw, MDa . | Capsid Mw, MDa . | Nucleic acid Mw, kDa . |
|---|---|---|---|
| hFIX-Padua | 4.53 ± 0.04 | 3.86 ± 0.01 | 666 ± 36 |
| An96 | 4.42 ± 0.08 | 3.81 ± 0.05 | 609 ± 32 |
| An96-Padua | 4.62 ± 0.08 | 3.74 ± 0.05 | 914 ± 390 |
Values are mean and standard deviation of 2 injections except An96-Padua (n = 1 because of lower titer and limited sample availability).