Table 2.

Multivariable analysis of predictors of cGVHD, disease relapse, and survival outcomes in patients who underwent allogeneic HSCT for AML and MDS (N = 350)

HR95% CIP
Predictors of cGVHD    
 Mismatched SIRPα 1.4 1.02-2.1 .04 
 Mismatched donor/recipient CMV status* 1.7 1.2-2.4 .004 
Predictors of disease relapse    
 Mismatched SIRPα 0.6† 0.3-1.1 .08 
 Not in remission at HSCT 1.9 1.4-2.9 <.01 
 ELN adverse risk for AML 1.6 1.04-2.3 .03 
Predictors of NRM    
 Mismatched SIRPα 0.97‡ 0.5-1.8 .9 
 HSCT-CI ≥ 3 2.1 1.2-3.9 .01 
 Not in remission at HSCT 1.9 1.03-3.6 .04 
Predictors of RFS    
 Mismatched SIRPα 0.6† 0.4-1.0 .05 
 Not in remission at HSCT 2.5 1.8-3.4 <.001 
 ELN adverse risk for AML 1.6 1.1-2.3 .005 
 Age > 60 y 1.5 1.1-2 .02 
Predictors of OS    
 Mismatched SIRPα 0.9‡ 0.6-1.3 .6 
 Not in remission at HSCT 2.4 1.7-3.4 <.001 
 Age > 60 y 1.6 1.1-2.2 .01 
 ELN adverse risk for AML 1.7 1.2-2.4 .003 
 Donor and recipient are CMV reactive 1.4 1.02-1.9 .03 
HR95% CIP
Predictors of cGVHD    
 Mismatched SIRPα 1.4 1.02-2.1 .04 
 Mismatched donor/recipient CMV status* 1.7 1.2-2.4 .004 
Predictors of disease relapse    
 Mismatched SIRPα 0.6† 0.3-1.1 .08 
 Not in remission at HSCT 1.9 1.4-2.9 <.01 
 ELN adverse risk for AML 1.6 1.04-2.3 .03 
Predictors of NRM    
 Mismatched SIRPα 0.97‡ 0.5-1.8 .9 
 HSCT-CI ≥ 3 2.1 1.2-3.9 .01 
 Not in remission at HSCT 1.9 1.03-3.6 .04 
Predictors of RFS    
 Mismatched SIRPα 0.6† 0.4-1.0 .05 
 Not in remission at HSCT 2.5 1.8-3.4 <.001 
 ELN adverse risk for AML 1.6 1.1-2.3 .005 
 Age > 60 y 1.5 1.1-2 .02 
Predictors of OS    
 Mismatched SIRPα 0.9‡ 0.6-1.3 .6 
 Not in remission at HSCT 2.4 1.7-3.4 <.001 
 Age > 60 y 1.6 1.1-2.2 .01 
 ELN adverse risk for AML 1.7 1.2-2.4 .003 
 Donor and recipient are CMV reactive 1.4 1.02-1.9 .03 

Mismatched SIRPα included mismatches in either direction (G vs H).

*

Mismatched: nonreactive/reactive or reactive/nonreactive.

†

HR adjusted for interaction with time.

‡

SIRPα variation was forced into the multivariable model.

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