Association of individual variables included in EASIX scores and severe CRS/ICANS
| Variable . | Median (range) . | N . | OR . | 95% CI . | P value . |
|---|---|---|---|---|---|
| Severe CRS | |||||
| At start of lymphodepletion | |||||
| LDH* (U/L) | 227 (110, 8255) | 112 | 1.17 | 0.55, 2.24 | .7 |
| Creatinine (mg/dL) | 0.80 (0.30, 2.00) | 118 | 0.05 | 0.00, 0.49 | .018 |
| PLTs° (k/μL) | 14 (1, 49) | 118 | 0.87 | 0.80, 0.94 | <.001 |
| CRP* (mg/L) | 1.3 (0.0, 28.5) | 84 | 1.87 | 1.21, 3.18 | .01 |
| At day − 1 | |||||
| LDH* (U/L) | 232 (106, 4110) | 112 | 1.66 | 0.81, 3.30 | .15 |
| Creatinine (mg/dL) | 0.70 (0.30, 1.60) | 118 | 0.22 | 0.02, 1.68 | .2 |
| PLTs° (k/μL) | 12 (1, 44) | 118 | 0.87 | 0.80, 0.94 | .001 |
| CRP* (mg/L) | 2.0 (0.0, 28.1) | 103 | 1.64 | 1.13, 2.51 | .014 |
| At day + 1 | |||||
| LDH* (U/L) | 207 (95, 2645) | 112 | 1.63 | 0.75, 3.42 | .2 |
| Creatinine (mg/dL) | 0.70 (0.30, 1.60) | 118 | 0.29 | 0.03, 2.35 | .3 |
| PLTs° (k/μL) | 11 (1, 38) | 118 | 0.84 | 0.76, 0.92 | <.001 |
| CRP* (mg/L) | 2.2 (0.1, 27.0) | 104 | 1.83 | 1.20, 2.98 | .009 |
| Severe ICANS | |||||
| At day + 1 | |||||
| LDH* (U/L) | 207 (95, 2645) | 112 | 1.39 | 0.71, 2.70 | .3 |
| Creatinine (mg/dL) | 0.70 (0.30, 1.60) | 118 | 0.3 | 0.04, 1.70 | .2 |
| PLTs° (k/μL) | 11 (1, 38) | 118 | 0.91 | 0.85, 0.97 | .004 |
| CRP* (mg/L) | 2.2 (0.1, 27.0) | 104 | 1.54 | 1.11, 2.21 | .013 |
| At day +3 | |||||
| LDH* (U/L) | 202 (96, 1810) | 103 | 1.17 | 0.54, 2.46 | .7 |
| Creatinine (mg/dL) | 0.70 (0.30, 1.80) | 118 | 0.91 | 0.21, 3.52 | .9 |
| PLTs† (/μL) | 8 (1, 34) | 118 | 0.85 | 0.78, 0.92 | <.001 |
| CRP* (mg/L) | 7 (0, 33) | 105 | 2.19 | 1.44, 3.63 | <.001 |
| Variable . | Median (range) . | N . | OR . | 95% CI . | P value . |
|---|---|---|---|---|---|
| Severe CRS | |||||
| At start of lymphodepletion | |||||
| LDH* (U/L) | 227 (110, 8255) | 112 | 1.17 | 0.55, 2.24 | .7 |
| Creatinine (mg/dL) | 0.80 (0.30, 2.00) | 118 | 0.05 | 0.00, 0.49 | .018 |
| PLTs° (k/μL) | 14 (1, 49) | 118 | 0.87 | 0.80, 0.94 | <.001 |
| CRP* (mg/L) | 1.3 (0.0, 28.5) | 84 | 1.87 | 1.21, 3.18 | .01 |
| At day − 1 | |||||
| LDH* (U/L) | 232 (106, 4110) | 112 | 1.66 | 0.81, 3.30 | .15 |
| Creatinine (mg/dL) | 0.70 (0.30, 1.60) | 118 | 0.22 | 0.02, 1.68 | .2 |
| PLTs° (k/μL) | 12 (1, 44) | 118 | 0.87 | 0.80, 0.94 | .001 |
| CRP* (mg/L) | 2.0 (0.0, 28.1) | 103 | 1.64 | 1.13, 2.51 | .014 |
| At day + 1 | |||||
| LDH* (U/L) | 207 (95, 2645) | 112 | 1.63 | 0.75, 3.42 | .2 |
| Creatinine (mg/dL) | 0.70 (0.30, 1.60) | 118 | 0.29 | 0.03, 2.35 | .3 |
| PLTs° (k/μL) | 11 (1, 38) | 118 | 0.84 | 0.76, 0.92 | <.001 |
| CRP* (mg/L) | 2.2 (0.1, 27.0) | 104 | 1.83 | 1.20, 2.98 | .009 |
| Severe ICANS | |||||
| At day + 1 | |||||
| LDH* (U/L) | 207 (95, 2645) | 112 | 1.39 | 0.71, 2.70 | .3 |
| Creatinine (mg/dL) | 0.70 (0.30, 1.60) | 118 | 0.3 | 0.04, 1.70 | .2 |
| PLTs° (k/μL) | 11 (1, 38) | 118 | 0.91 | 0.85, 0.97 | .004 |
| CRP* (mg/L) | 2.2 (0.1, 27.0) | 104 | 1.54 | 1.11, 2.21 | .013 |
| At day +3 | |||||
| LDH* (U/L) | 202 (96, 1810) | 103 | 1.17 | 0.54, 2.46 | .7 |
| Creatinine (mg/dL) | 0.70 (0.30, 1.80) | 118 | 0.91 | 0.21, 3.52 | .9 |
| PLTs† (/μL) | 8 (1, 34) | 118 | 0.85 | 0.78, 0.92 | <.001 |
| CRP* (mg/L) | 7 (0, 33) | 105 | 2.19 | 1.44, 3.63 | <.001 |