Detection of translocations by EuroClonality-NDC in different disease entities
| . | Total cases* . | Translocations detected . | ALK . | STIL-TAL1 . | Breakpoints in TCR loci . | BIRC3-MALT1 . | Breakpoints in IG loci† . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Benchmark . | NGS . | HOXA . | LMO1/2 . | TLX1 . | CRLF2 . | BCL2 . | BCL6 . | MYC . | CCND1 . | MAF . | |||||
| ALCL | 12 | 9 | 9 | 9 | |||||||||||
| T-ALL | 38 | 29 | 29 | 5 | 4 | 5 | 7 | ||||||||
| B-ALL | 18 | 11 | 12 | 7 | 1 (1) | 4 (1) | |||||||||
| BL | 11 | 11 | 10 | 1 (1) | 10 (1) | ||||||||||
| CLL | 33 | 8 | 8 | 4 | |||||||||||
| DLBCL | 17 | 12 | 11 | 7 (2) | 2 (1) | 4 (2) | |||||||||
| FL | 33 | 29 | 28 | 28 | |||||||||||
| MCL | 29 | 28 | 26 | 1(1) | 26 (1) | ||||||||||
| PCM | 22 | 13 | 12 | 5 | 4 | ||||||||||
| MZL | 6 | 2 | 2 | 1 | 1 | ||||||||||
| . | Total cases* . | Translocations detected . | ALK . | STIL-TAL1 . | Breakpoints in TCR loci . | BIRC3-MALT1 . | Breakpoints in IG loci† . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Benchmark . | NGS . | HOXA . | LMO1/2 . | TLX1 . | CRLF2 . | BCL2 . | BCL6 . | MYC . | CCND1 . | MAF . | |||||
| ALCL | 12 | 9 | 9 | 9 | |||||||||||
| T-ALL | 38 | 29 | 29 | 5 | 4 | 5 | 7 | ||||||||
| B-ALL | 18 | 11 | 12 | 7 | 1 (1) | 4 (1) | |||||||||
| BL | 11 | 11 | 10 | 1 (1) | 10 (1) | ||||||||||
| CLL | 33 | 8 | 8 | 4 | |||||||||||
| DLBCL | 17 | 12 | 11 | 7 (2) | 2 (1) | 4 (2) | |||||||||
| FL | 33 | 29 | 28 | 28 | |||||||||||
| MCL | 29 | 28 | 26 | 1(1) | 26 (1) | ||||||||||
| PCM | 22 | 13 | 12 | 5 | 4 | ||||||||||
| MZL | 6 | 2 | 2 | 1 | 1 | ||||||||||
MZL, marginal zone lymphoma; PCM, plasma cell myeloma.
Of the 270 samples used for IG/TCR rearrangement analysis, 27 samples were excluded from translocation analysis by the internal review committee. Only disease entities with recurrent translocations partners are shown.
Figures within parentheses indicate the number of translocations, with the specified IG translocation partner, which were found as a double-hit event within a particular disease entity. Only common recurrent translocation partners are detailed.