Markers with significant change over time (n = 15) in HCT-treated patients with MPS I
| Marker . | Slope* . | P . | Pathway . | Differentiating pre-HCT . |
|---|---|---|---|---|
| CXCL9 | −0.09 | .049 | Pro-inflammatory | Yes |
| CXCL10 | −0.12 | .04 | Pro-inflammatory | No |
| CCL3 | −0.13 | .01 | Pro-inflammatory | No |
| CCL4 | −0.10 | .02 | Pro-inflammatory | Yes |
| CCL19 | −0.09 | .03 | Pro-inflammatory | No |
| CCL20 | −0.09 | .04 | Pro-inflammatory | No |
| CCL25 | −0.08 | .02 | Pro-inflammatory | No |
| MCP.3 | −0.07 | .03 | Pro-inflammatory | No |
| IFN.γ | −0.12 | .04 | Pro-inflammatory | No |
| TNF | −0.07 | .009 | Pro-inflammatory | No |
| TNFB | −0.06 | .04 | Pro-inflammatory | No |
| TNFRSF9 | −0.08 | .009 | Pro-inflammatory | No |
| CDCP1 | −0.06 | .04 | Pro-inflammatory | No |
| Flt3L | 0.1 | .03 | Growth factor/bone homeostasis | No |
| SCF | 0.1 | .03 | Growth factor/bone homeostasis | Yes |
| Marker . | Slope* . | P . | Pathway . | Differentiating pre-HCT . |
|---|---|---|---|---|
| CXCL9 | −0.09 | .049 | Pro-inflammatory | Yes |
| CXCL10 | −0.12 | .04 | Pro-inflammatory | No |
| CCL3 | −0.13 | .01 | Pro-inflammatory | No |
| CCL4 | −0.10 | .02 | Pro-inflammatory | Yes |
| CCL19 | −0.09 | .03 | Pro-inflammatory | No |
| CCL20 | −0.09 | .04 | Pro-inflammatory | No |
| CCL25 | −0.08 | .02 | Pro-inflammatory | No |
| MCP.3 | −0.07 | .03 | Pro-inflammatory | No |
| IFN.γ | −0.12 | .04 | Pro-inflammatory | No |
| TNF | −0.07 | .009 | Pro-inflammatory | No |
| TNFB | −0.06 | .04 | Pro-inflammatory | No |
| TNFRSF9 | −0.08 | .009 | Pro-inflammatory | No |
| CDCP1 | −0.06 | .04 | Pro-inflammatory | No |
| Flt3L | 0.1 | .03 | Growth factor/bone homeostasis | No |
| SCF | 0.1 | .03 | Growth factor/bone homeostasis | Yes |
CCL, C-C motif chemokine ligand; CXCL, C-C-C motif chemokine ligand; IFN, interferon; MCP, monocyte chemoattractant protein; SCF, stem cell factor; TNF-a, tumor necrosis factor alpha; TNFRSF, tumor necrosis factor receptor superfamily
The slope of the linear mixed model indicates the change in NPX unit per year.