Table 1. Top 10 AS genes with... | American Society of Hematology

Table 1.

Top 10 AS genes with experimental validated function in HSC aging

Gene symbol	Consistency (out of 12)	Average log₂FC	Function	Phenotype	References
Itgb3	9	1.25 ± 0.48	Cell adhesion; signal transduction	Itgb3^high identifies myeloid-biased HSCs	17,39
Vwf	8	1.37 ± 0.66	Cell adhesion; signal transduction	Vwf^high identifies myeloid-biased HSCs	14,40,41
Neo1	8	1.84 ± 1.18	Cell adhesion; signal transduction	Neo1^high identifies more dormant HSCs	26,42
Alcam	8	1.39 ± 0.62	Cell adhesion	Alcam⁺ identifies myeloid-biased HSCs and with reduced potential	43
CD86	6	−1.39 ± 0.36	Signal transduction	Required for lymphoid differentiation	44
Gadd45g	6	1.54 ± 0.99	Stress response	Gadd45g⁻^/⁻ shows increased self-renewal and deficient megakaryocytic differentiation	45
Satb1	6	−1.21 ± 0.50	Epigenetic effector	Required for lymphoid differentiation	46
Sdpr	6	1.88 ± 1.61	Transcription regulation	Involved in PRC2 expression regulation	47
Slamf1	5	0.92 ± 0.16	Cell adhesion; signal transduction	Slamf1^high identifies myeloid-biased HSCs with reduced potential	48,49
Dnmt3b	4	−1.09 ± 0.62	Epigenetic regulator	Dnmt3a/b^−/− shows differentiation blockage/increased self-renewal	29,50,51

Gene symbol	Consistency (out of 12)	Average log₂FC	Function	Phenotype	References
Itgb3	9	1.25 ± 0.48	Cell adhesion; signal transduction	Itgb3^high identifies myeloid-biased HSCs	17,39
Vwf	8	1.37 ± 0.66	Cell adhesion; signal transduction	Vwf^high identifies myeloid-biased HSCs	14,40,41
Neo1	8	1.84 ± 1.18	Cell adhesion; signal transduction	Neo1^high identifies more dormant HSCs	26,42
Alcam	8	1.39 ± 0.62	Cell adhesion	Alcam⁺ identifies myeloid-biased HSCs and with reduced potential	43
CD86	6	−1.39 ± 0.36	Signal transduction	Required for lymphoid differentiation	44
Gadd45g	6	1.54 ± 0.99	Stress response	Gadd45g⁻^/⁻ shows increased self-renewal and deficient megakaryocytic differentiation	45
Satb1	6	−1.21 ± 0.50	Epigenetic effector	Required for lymphoid differentiation	46
Sdpr	6	1.88 ± 1.61	Transcription regulation	Involved in PRC2 expression regulation	47
Slamf1	5	0.92 ± 0.16	Cell adhesion; signal transduction	Slamf1^high identifies myeloid-biased HSCs with reduced potential	48,49
Dnmt3b	4	−1.09 ± 0.62	Epigenetic regulator	Dnmt3a/b^−/− shows differentiation blockage/increased self-renewal	29,50,51