Hematologic parameters for Neo1fl/fl;Alb-Cre−, Neo1fl/wt;Alb-Cre+, and Neo1fl/fl;Alb-Cr+ male mice
| . | Neo1fl/fl;Alb-Cre− (5 wk) (n = 5) . | Neo1fl/fl;Alb-Cre+ (5 wk) (n = 6) . | Neo1fl/fl;Alb-Cre− (8 wk) (n = 15) . | Neo1fllwt;Alb-Cre+ (8 wk) (n = 5) . | Neo1fl/fl;Alb-Cre+ (8 wk) (n = 8) . | Neo1fl/fl;Alb-Cre− (15 wk) (n = 7) . | Neo1fl/fl;Alb-Cre+ (15 wk) (n = 4) . |
|---|---|---|---|---|---|---|---|
| RBC | 8.34 ± 0.36 | 8.42 ± 0.22 | 8.75 ± 0.35 | 8.53 ± 0.50 | 8.87 ± 0.29 | 8.85 ± 0.42 | 8.91 ± 0.15 |
| Hb | 12.40 ± 0.16 | 12.78 ± 0.27* | 12.54 ± 0.49 | 12.29 ± 0.53 | 13.33 ± 0.29† | 13.03 ± 0.41 | 13.77 ± 0.59‡ |
| HCT | 42.70 ± 2.28 | 43.86 ± 0.86* | 39.64 ± 1.86 | 39.48 ± 1.97 | 42.51 ± 1.38‡ | 39.43 ± 0.90 | 43.22 ± 1.89‡ |
| MCV | 48.02 ± 1.73 | 50.11 ± 0.89* | 45.34 ± 0.89 | 45.96 ± 1.53 | 47.90 ± 0.79† | 44.58 ± 1.99 | 48.47 ± 1.77* |
| MCH | 14.57 ± 0.24 | 15.01 ± 0.26* | 14.38 ± 0.44 | 14.54 ± 0.22 | 15.02 ± 0.35‡ | 14.74 ± 0.63 | 15.45 ± 0.55* |
| . | Neo1fl/fl;Alb-Cre− (5 wk) (n = 5) . | Neo1fl/fl;Alb-Cre+ (5 wk) (n = 6) . | Neo1fl/fl;Alb-Cre− (8 wk) (n = 15) . | Neo1fllwt;Alb-Cre+ (8 wk) (n = 5) . | Neo1fl/fl;Alb-Cre+ (8 wk) (n = 8) . | Neo1fl/fl;Alb-Cre− (15 wk) (n = 7) . | Neo1fl/fl;Alb-Cre+ (15 wk) (n = 4) . |
|---|---|---|---|---|---|---|---|
| RBC | 8.34 ± 0.36 | 8.42 ± 0.22 | 8.75 ± 0.35 | 8.53 ± 0.50 | 8.87 ± 0.29 | 8.85 ± 0.42 | 8.91 ± 0.15 |
| Hb | 12.40 ± 0.16 | 12.78 ± 0.27* | 12.54 ± 0.49 | 12.29 ± 0.53 | 13.33 ± 0.29† | 13.03 ± 0.41 | 13.77 ± 0.59‡ |
| HCT | 42.70 ± 2.28 | 43.86 ± 0.86* | 39.64 ± 1.86 | 39.48 ± 1.97 | 42.51 ± 1.38‡ | 39.43 ± 0.90 | 43.22 ± 1.89‡ |
| MCV | 48.02 ± 1.73 | 50.11 ± 0.89* | 45.34 ± 0.89 | 45.96 ± 1.53 | 47.90 ± 0.79† | 44.58 ± 1.99 | 48.47 ± 1.77* |
| MCH | 14.57 ± 0.24 | 15.01 ± 0.26* | 14.38 ± 0.44 | 14.54 ± 0.22 | 15.02 ± 0.35‡ | 14.74 ± 0.63 | 15.45 ± 0.55* |
Data are expressed as means ± SD. A 2-tailed Student t test was used for statistical analysis between Neo1fl/wt;Alb-Cr+ mice and the age-matched Neo1fl/fl;Alb-Cre− control group at 5 and 15 wk old. One-way ANOVA and Tukey’s posttests were used to compare 8-wk-old mice.
Hb, hemoglobin (g/dL); HCT, hematocrit (%); MCV, mean cell volume (fL); MCH, mean corpuscular hemoglobin (pg); RBC, red blood cell (×106/µL).
P < .05.
P < .001.
P < .01.