Multivariate analysis of event-free survival among patients with B-ALL or T-ALL
| Variables . | Patients with B-ALL . | Patients with T-ALL . | ||||||
|---|---|---|---|---|---|---|---|---|
| No. of patients . | No. of events . | HR (95% CI) . | P . | No. of patients . | No. of events . | HR (95% CI) . | P . | |
| Age at diagnosis, y | ||||||||
| 1-9.9 | 5605 | 551 | 1.0 | 435 | 80 | 1.0 | ||
| ≥10 | 733 | 131 | 1.5 (1.2-1.9) | <.001 | 207 | 41 | 1.0 (0.7-1.5) | .97 |
| <1 | 99 | 20 | 1.2 (0.7-1.9) | .55 | 2 | 1 | 2.0 (0.3-15.9) | .52 |
| Sex | ||||||||
| Female | 2737 | 260 | 1.0 | 163 | 35 | 1.0 | ||
| Male | 3700 | 442 | 1.2 (1.0-1.4) | .02 | 481 | 87 | 0.8 (0.5-1.2) | .32 |
| Leukocyte count, ×109/L | ||||||||
| <50 | 5378 | 496 | 1.0 | 261 | 44 | 1.0 | ||
| ≥50 | 1059 | 206 | 1.6 (1.3-1.9) | <.001 | 383 | 78 | 1.4 (0.9-2.0) | .11 |
| CNS status | ||||||||
| CNS1 | 5986 | 647 | 1.0 | 584 | 106 | 1.0 | ||
| CNS2 | 89 | 19 | 1.7 (1.1-2.8) | .02 | 15 | 4 | 1.3 (0.5-3.7) | .57 |
| Traumatic lumbar puncture | 313 | 22 | 0.7 (0.5-1.1) | .09 | 26 | 7 | 1.8 (0.8-3.9) | .15 |
| CNS3 | 49 | 14 | 2.7 (1.6-4.6) | <.001 | 19 | 5 | 1.7 (0.6-4.2) | .29 |
| Ploidy* | ||||||||
| Hyperdiploidy >50 | 995 | 90 | 1.0 | – | – | – | ||
| Others | 5442 | 612 | 1.3 (1.0-1.6) | .03 | – | – | – | – |
| t(9;22)(BCR-ABL1) | ||||||||
| Absent | 6135 | 630 | 1.0 | 638 | 119 | 1.0 | ||
| Present | 302 | 72 | 1.4 (1.1-1.9) | .01 | 6 | 3 | 4.9 (1.5-15.6) | .008 |
| KMT2A rearrangement* | ||||||||
| Absent | 6261 | 647 | 1.0 | – | – | – | ||
| Present | 176 | 55 | 3.3 (2.4-4.6) | <.001 | – | – | – | – |
| t(12;21)(ETV6-RUNX1) | ||||||||
| Present | 1373 | 75 | 1.0 | – | – | – | ||
| Absent | 5064 | 627 | 1.7 (1.3-2.2) | <.001 | – | – | – | – |
| MRD on day 19 of induction, % | ||||||||
| <0.01 | 3125 | 191 | 1.0 | 274 | 40 | 1.0 | ||
| 0.01-0.09 | 978 | 96 | 1.6 (1.2-2.0) | <.001 | 26 | 3 | 0.8 (0.2-2.7) | .73 |
| 0.1-0.99 | 1296 | 197 | 2.1 (1.7-2.6) | <.001 | 75 | 13 | 1.3 (0.7-2.5) | .41 |
| ≥1 | 1038 | 218 | 2.1 (1.6-2.6) | <.001 | 269 | 66 | 1.2 (0.8-2.0) | .38 |
| MRD on day 46 of induction, % | ||||||||
| <0.01 | 5597 | 476 | 1.0 | 519 | 83 | 1.0 | ||
| 0.01-0.09 | 483 | 91 | 1.6 (1.3-2.1) | <.001 | 42 | 8 | 1.2 (0.5-2.6) | .64 |
| 0.1-0.99 | 254 | 85 | 2.9 (2.3-3.8) | <.001 | 42 | 12 | 2.1 (1.1-4.1) | .03 |
| ≥1 | 103 | 50 | 7.8 (5.7-10.9) | <.001 | 41 | 19 | 7.2 (4.0-12.9) | <.001 |
| Variables . | Patients with B-ALL . | Patients with T-ALL . | ||||||
|---|---|---|---|---|---|---|---|---|
| No. of patients . | No. of events . | HR (95% CI) . | P . | No. of patients . | No. of events . | HR (95% CI) . | P . | |
| Age at diagnosis, y | ||||||||
| 1-9.9 | 5605 | 551 | 1.0 | 435 | 80 | 1.0 | ||
| ≥10 | 733 | 131 | 1.5 (1.2-1.9) | <.001 | 207 | 41 | 1.0 (0.7-1.5) | .97 |
| <1 | 99 | 20 | 1.2 (0.7-1.9) | .55 | 2 | 1 | 2.0 (0.3-15.9) | .52 |
| Sex | ||||||||
| Female | 2737 | 260 | 1.0 | 163 | 35 | 1.0 | ||
| Male | 3700 | 442 | 1.2 (1.0-1.4) | .02 | 481 | 87 | 0.8 (0.5-1.2) | .32 |
| Leukocyte count, ×109/L | ||||||||
| <50 | 5378 | 496 | 1.0 | 261 | 44 | 1.0 | ||
| ≥50 | 1059 | 206 | 1.6 (1.3-1.9) | <.001 | 383 | 78 | 1.4 (0.9-2.0) | .11 |
| CNS status | ||||||||
| CNS1 | 5986 | 647 | 1.0 | 584 | 106 | 1.0 | ||
| CNS2 | 89 | 19 | 1.7 (1.1-2.8) | .02 | 15 | 4 | 1.3 (0.5-3.7) | .57 |
| Traumatic lumbar puncture | 313 | 22 | 0.7 (0.5-1.1) | .09 | 26 | 7 | 1.8 (0.8-3.9) | .15 |
| CNS3 | 49 | 14 | 2.7 (1.6-4.6) | <.001 | 19 | 5 | 1.7 (0.6-4.2) | .29 |
| Ploidy* | ||||||||
| Hyperdiploidy >50 | 995 | 90 | 1.0 | – | – | – | ||
| Others | 5442 | 612 | 1.3 (1.0-1.6) | .03 | – | – | – | – |
| t(9;22)(BCR-ABL1) | ||||||||
| Absent | 6135 | 630 | 1.0 | 638 | 119 | 1.0 | ||
| Present | 302 | 72 | 1.4 (1.1-1.9) | .01 | 6 | 3 | 4.9 (1.5-15.6) | .008 |
| KMT2A rearrangement* | ||||||||
| Absent | 6261 | 647 | 1.0 | – | – | – | ||
| Present | 176 | 55 | 3.3 (2.4-4.6) | <.001 | – | – | – | – |
| t(12;21)(ETV6-RUNX1) | ||||||||
| Present | 1373 | 75 | 1.0 | – | – | – | ||
| Absent | 5064 | 627 | 1.7 (1.3-2.2) | <.001 | – | – | – | – |
| MRD on day 19 of induction, % | ||||||||
| <0.01 | 3125 | 191 | 1.0 | 274 | 40 | 1.0 | ||
| 0.01-0.09 | 978 | 96 | 1.6 (1.2-2.0) | <.001 | 26 | 3 | 0.8 (0.2-2.7) | .73 |
| 0.1-0.99 | 1296 | 197 | 2.1 (1.7-2.6) | <.001 | 75 | 13 | 1.3 (0.7-2.5) | .41 |
| ≥1 | 1038 | 218 | 2.1 (1.6-2.6) | <.001 | 269 | 66 | 1.2 (0.8-2.0) | .38 |
| MRD on day 46 of induction, % | ||||||||
| <0.01 | 5597 | 476 | 1.0 | 519 | 83 | 1.0 | ||
| 0.01-0.09 | 483 | 91 | 1.6 (1.3-2.1) | <.001 | 42 | 8 | 1.2 (0.5-2.6) | .64 |
| 0.1-0.99 | 254 | 85 | 2.9 (2.3-3.8) | <.001 | 42 | 12 | 2.1 (1.1-4.1) | .03 |
| ≥1 | 103 | 50 | 7.8 (5.7-10.9) | <.001 | 41 | 19 | 7.2 (4.0-12.9) | <.001 |
Factors not included in the multivariate analysis for T-ALL because the numbers of patients were too small for analyses.