Comparison of AITL score with established prognostic indices
| Prognostic index . | IPI . | PIT . | PIAI . | AITL score . | |||||
|---|---|---|---|---|---|---|---|---|---|
| Risk group (score) | Low (0-2) | High (3-5) | Low (0-1) | High (2-4) | Low (0-1) | High (2-5) | Low (0-1) | Intermediate (2) | High (3-4) |
| n (%) | 81/183 (44) | 102/183 (56) | 70/183 (38) | 113/183 (62) | 68/183 (37) | 115/183 (63) | 16/96 (17) | 22/96 (23) | 58/96 (60) |
| Median PFS (95% CI), mo | 34 (12-57) | 8 (5-11) | 29 (18-41) | 9 (4-14) | 46 (13-59) | 13 (7-19) | 31 (13-NR) | 12 (8-16) | 9 (4-15) |
| 5-y PFS (95% CI), % | 40 (21-65) | 25 (9-48) | 37 (17-52) | 27 (9-41) | 44 (14-66) | 24 (8-36) | 41 (17-62) | 37 (9-41) | 13 (7-26) |
| P value | .0006 | .03 | .0006 | .003 | |||||
| Median OS (95% CI), mo | NR | 16 | NR | 17 (4-31) | NR | 24 (1-48) | NR | 35 (14-44) | 20 (6-30) |
| 5-y OS (95% CI), % | 61 (23-79) | 32 (11-51) | 64 (21-81) | 29 (10-50) | 61 (14-72) | 36 (14-49) | 63 (20-68) | 54 (10-67) | 21 (11-32) |
| P | .0005 | .0002 | .001 | .0003 | |||||
| Harrell C-statistic | 0.697 | 0.648 | 0.711 | 0.785 | |||||
| AIC global fit | 566.4 | 575.3 | 543.4 | 524.0 | |||||
| Prognostic index . | IPI . | PIT . | PIAI . | AITL score . | |||||
|---|---|---|---|---|---|---|---|---|---|
| Risk group (score) | Low (0-2) | High (3-5) | Low (0-1) | High (2-4) | Low (0-1) | High (2-5) | Low (0-1) | Intermediate (2) | High (3-4) |
| n (%) | 81/183 (44) | 102/183 (56) | 70/183 (38) | 113/183 (62) | 68/183 (37) | 115/183 (63) | 16/96 (17) | 22/96 (23) | 58/96 (60) |
| Median PFS (95% CI), mo | 34 (12-57) | 8 (5-11) | 29 (18-41) | 9 (4-14) | 46 (13-59) | 13 (7-19) | 31 (13-NR) | 12 (8-16) | 9 (4-15) |
| 5-y PFS (95% CI), % | 40 (21-65) | 25 (9-48) | 37 (17-52) | 27 (9-41) | 44 (14-66) | 24 (8-36) | 41 (17-62) | 37 (9-41) | 13 (7-26) |
| P value | .0006 | .03 | .0006 | .003 | |||||
| Median OS (95% CI), mo | NR | 16 | NR | 17 (4-31) | NR | 24 (1-48) | NR | 35 (14-44) | 20 (6-30) |
| 5-y OS (95% CI), % | 61 (23-79) | 32 (11-51) | 64 (21-81) | 29 (10-50) | 61 (14-72) | 36 (14-49) | 63 (20-68) | 54 (10-67) | 21 (11-32) |
| P | .0005 | .0002 | .001 | .0003 | |||||
| Harrell C-statistic | 0.697 | 0.648 | 0.711 | 0.785 | |||||
| AIC global fit | 566.4 | 575.3 | 543.4 | 524.0 | |||||
NR, not reached.