Univariate and multivariate analyses of prognostic factors
| Variable . | Univariate analysis . | Multivariate analysis . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PFS . | OS . | PFS . | OS . | |||||||||
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Age ≥40 y | 0.85 | 0.57-1.27 | .421 | 0.95 | 0.62-1.46 | .818 | ||||||
| Sex | 0.93 | 0.54-1.62 | .802 | 0.99 | 0.56-1.75 | .964 | ||||||
| LDH> ULN | 2.75 | 1.28-5.91 | .009 | 3.32 | 1.35-8.13 | .008 | ||||||
| LDH> 5× ULN | 2.86 | 1.91-4.29 | <.001 | 3.15 | 2.05-4.86 | <.001 | 2.09 | 1.35-3.23 | <.001 | 2.26 | 1.42-3.59 | <.001 |
| Advanced stage | 1.67 | 0.73-3.82 | .222 | 1.87 | 0.76-4.61 | .173 | ||||||
| ECOG PS 2-4 | 2.45 | 1.60-3.77 | <.001 | 2.73 | 1.72-4.34 | <.001 | 1.87 | 1.18-2.96 | .007 | 2.00 | 1.22-3.28 | .006 |
| CNS involvement | 2.68 | 1.75-4.10 | <.001 | 2.99 | 1.90-4.70 | <.001 | 1.70 | 1.08-2.70 | .023 | 1.83 | 1.12-2.98 | .015 |
| >1 EN | 1.89 | 1.23-2.91 | .003 | 2.04 | 1.29-3.23 | .002 | 1.58 | 1.01-2.47 | .043 | 1.71 | 1.06-2.75 | .027 |
| BM involvement | 1.91 | 1.28-2.86 | .001 | 2.21 | 1.43-3.41 | <.001 | ||||||
| Undetectable viral load | 0.93 | 0.57-1.52 | .783 | 1.01 | 0.61-1.68 | .965 | ||||||
| CD4 < > 100 cells/µL | 1.59 | 1.03-2.45 | .038 | 1.66 | 1.05-2.62 | .02 | ||||||
| cART | 0.88 | 0.58-1.34 | .555 | 0.96 | 0.62-1.49 | .857 | ||||||
| Variable . | Univariate analysis . | Multivariate analysis . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PFS . | OS . | PFS . | OS . | |||||||||
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Age ≥40 y | 0.85 | 0.57-1.27 | .421 | 0.95 | 0.62-1.46 | .818 | ||||||
| Sex | 0.93 | 0.54-1.62 | .802 | 0.99 | 0.56-1.75 | .964 | ||||||
| LDH> ULN | 2.75 | 1.28-5.91 | .009 | 3.32 | 1.35-8.13 | .008 | ||||||
| LDH> 5× ULN | 2.86 | 1.91-4.29 | <.001 | 3.15 | 2.05-4.86 | <.001 | 2.09 | 1.35-3.23 | <.001 | 2.26 | 1.42-3.59 | <.001 |
| Advanced stage | 1.67 | 0.73-3.82 | .222 | 1.87 | 0.76-4.61 | .173 | ||||||
| ECOG PS 2-4 | 2.45 | 1.60-3.77 | <.001 | 2.73 | 1.72-4.34 | <.001 | 1.87 | 1.18-2.96 | .007 | 2.00 | 1.22-3.28 | .006 |
| CNS involvement | 2.68 | 1.75-4.10 | <.001 | 2.99 | 1.90-4.70 | <.001 | 1.70 | 1.08-2.70 | .023 | 1.83 | 1.12-2.98 | .015 |
| >1 EN | 1.89 | 1.23-2.91 | .003 | 2.04 | 1.29-3.23 | .002 | 1.58 | 1.01-2.47 | .043 | 1.71 | 1.06-2.75 | .027 |
| BM involvement | 1.91 | 1.28-2.86 | .001 | 2.21 | 1.43-3.41 | <.001 | ||||||
| Undetectable viral load | 0.93 | 0.57-1.52 | .783 | 1.01 | 0.61-1.68 | .965 | ||||||
| CD4 < > 100 cells/µL | 1.59 | 1.03-2.45 | .038 | 1.66 | 1.05-2.62 | .02 | ||||||
| cART | 0.88 | 0.58-1.34 | .555 | 0.96 | 0.62-1.49 | .857 | ||||||