Number of infusions required to resolve bleeding episodes
| . | Treatment regimen . | |
|---|---|---|
| On demand (n = 22) . | Prophylactic (n = 28) . | |
| No. of bleeding episodes | 27 | 58 |
| Per bleeding episode, n (%)* | ||
| 1 | 23 (85.2) | 51 (87.9) |
| 2 | 1 (3.7) | 5 (8.6) |
| 3 | 0 (0.0) | 1 (1.7) |
| 4 | 1 (3.7) | 1 (1.7) |
| >4 | 2 (7.4)† | 0 (0.0) |
| Infusions required to resolve bleeding episodes | ||
| Mean | 3.2 | 1.2 |
| SD | 7.4 | 0.5 |
| Median | 1.0 | 1.0 |
| IQR | 1.0-1.0 | 1.0-1.0 |
| Range | 1-31 | 1-4 |
| . | Treatment regimen . | |
|---|---|---|
| On demand (n = 22) . | Prophylactic (n = 28) . | |
| No. of bleeding episodes | 27 | 58 |
| Per bleeding episode, n (%)* | ||
| 1 | 23 (85.2) | 51 (87.9) |
| 2 | 1 (3.7) | 5 (8.6) |
| 3 | 0 (0.0) | 1 (1.7) |
| 4 | 1 (3.7) | 1 (1.7) |
| >4 | 2 (7.4)† | 0 (0.0) |
| Infusions required to resolve bleeding episodes | ||
| Mean | 3.2 | 1.2 |
| SD | 7.4 | 0.5 |
| Median | 1.0 | 1.0 |
| IQR | 1.0-1.0 | 1.0-1.0 |
| Range | 1-31 | 1-4 |
Investigators could treat patients with rFIXFc on demand at investigators’ discretion before initiating prophylaxis, in accordance with local standard of care. Therefore, patients may appear in >1 treatment regimen group. All infusions administered from initial sign of bleeding episode until last date/time within bleed window are counted.
SD, standard deviation.
Percentages are based on total number of bleeding episodes in each group.
One episode of spontaneous subdural hematoma in 1 patient; 1 episode of spontaneous spinal cord hematoma in 1 patient.