Table 1. Cell binding of UC-961 and... | American Society of Hematology

Table 1.

Cell binding of UC-961 and VLS-101

ROR1⁺ cell line	Cancer type	UC-961 EC₅₀, ng/mL	VLS-101 EC₅₀, ng/mL
JeKo-1	MCL	17.0	13.6
Patient sample #1	CLL	14.2	17.4
Patient sample #2	CLL	16.8	18.9
Patient sample #3	CLL	13.3	14.4

ROR1⁺ cell line	Cancer type	UC-961 EC₅₀, ng/mL	VLS-101 EC₅₀, ng/mL
JeKo-1	MCL	17.0	13.6
Patient sample #1	CLL	14.2	17.4
Patient sample #2	CLL	16.8	18.9
Patient sample #3	CLL	13.3	14.4

Cultured ROR1⁺ JeKo-1 cell line and 3 ROR1⁺ primary CLL patient samples were harvested and incubated at 4°C with UC-961 or VLS-101 followed by a fluorophore-conjugated secondary antibody and viability staining, and then analyzed by flow cytometry. The table provides the EC₅₀ of the viable cell population. Comparable data were obtained from at least 3 independent experiments.

View Large

This Feature Is Available To Subscribers Only