Summary of qPCR results in cross-sectional and longitudinal cohorts for cf-nDNA and cf-mtDNA
| Cohort . | Gene marker . | cf-nDNA (ng/mL) . | Gene marker . | cf-mtDNA (fold change) . | ||||
|---|---|---|---|---|---|---|---|---|
| HC . | SCD-Baseline . | SCD-Crisis . | HC . | SCD-Baseline . | SCD-Crisis . | |||
| Cross-sectional* | GAPDH | 6.85 | 9.65 | 22.01 | MT-ND1/GAPDH | 7.8 | 153.3 | 63.4 |
| MT-ND1/TERT | 5.4 | 44.1 | 40 | |||||
| TERT | 11.05 | 16.2 | 38.38 | MT-ND6/GAPDH | 19.1 | 142.3 | 70.5 | |
| MT-ND6/TERT | 9.7 | 44.4 | 46.4 | |||||
| Paired (n = 18) | GAPDH | 6.14 | 23.9 | MT-ND1/GAPDH | 65.7 | 63 | ||
| MT-ND1/TERT | 44.5 | 41.6 | ||||||
| TERT | 13.56 | 41.65 | MT-ND6/GAPDH | 81.5 | 76.8 | |||
| MT-ND6/TERT | 54.8 | 50.9 | ||||||
| Cohort . | Gene marker . | cf-nDNA (ng/mL) . | Gene marker . | cf-mtDNA (fold change) . | ||||
|---|---|---|---|---|---|---|---|---|
| HC . | SCD-Baseline . | SCD-Crisis . | HC . | SCD-Baseline . | SCD-Crisis . | |||
| Cross-sectional* | GAPDH | 6.85 | 9.65 | 22.01 | MT-ND1/GAPDH | 7.8 | 153.3 | 63.4 |
| MT-ND1/TERT | 5.4 | 44.1 | 40 | |||||
| TERT | 11.05 | 16.2 | 38.38 | MT-ND6/GAPDH | 19.1 | 142.3 | 70.5 | |
| MT-ND6/TERT | 9.7 | 44.4 | 46.4 | |||||
| Paired (n = 18) | GAPDH | 6.14 | 23.9 | MT-ND1/GAPDH | 65.7 | 63 | ||
| MT-ND1/TERT | 44.5 | 41.6 | ||||||
| TERT | 13.56 | 41.65 | MT-ND6/GAPDH | 81.5 | 76.8 | |||
| MT-ND6/TERT | 54.8 | 50.9 | ||||||
HC, n = 13; SCD-Baseline, n = 72; SCD-Crisis, n = 20.