Table 1.

Skin changes in patients receiving IMiD therapy

n (%)
Total surveys 106 
 No skin changes reported 79 (74.5) 
 Skin changes reported 27 (25.5) 
Description of skin changes 27 
 Pigmentation  
  Darkening (hyperpigmentation) 22 (81.5) 
  Lightening 2 (7.4) 
 Distribution  
  Spotty 9 (33.3) 
  Generalized 2 (7.4) 
  Other 6 (22.2) 
Location of hyperpigmentation 22 
 Palms/soles 15 (68.2) 
 Forearms 7 (31.8) 
 Face 6 (27.2) 
 Shins 3 (13.6) 
 Thighs 3 (13.6) 
 Chest 3 (13.6) 
 Everywhere 3 (13.6) 
 Other (back, abdomen, nails, fingers/toes, groin) 5 (22.7) 
Time to onset of hyperpigmentation, mo 22 
 <3 10 (45.5) 
 3-6 4 (18.2) 
 >6 6 (27.3) 
 Unsure 2 (9.1) 
Resolution of hyperpigmentation after IMiD discontinuation 11 
 Not better 2 (18.2) 
 Partially better 5 (45.5) 
 Fully resolved 4 (36.6) 
Score (1-10 scale) of distress caused by hyperpigmentation 22 
 More bothersome (7-10 of 10) 7 (31.8) 
 Less bothersome (1-6 of 10) 15 (68.2) 
 Range 1-9 
n (%)
Total surveys 106 
 No skin changes reported 79 (74.5) 
 Skin changes reported 27 (25.5) 
Description of skin changes 27 
 Pigmentation  
  Darkening (hyperpigmentation) 22 (81.5) 
  Lightening 2 (7.4) 
 Distribution  
  Spotty 9 (33.3) 
  Generalized 2 (7.4) 
  Other 6 (22.2) 
Location of hyperpigmentation 22 
 Palms/soles 15 (68.2) 
 Forearms 7 (31.8) 
 Face 6 (27.2) 
 Shins 3 (13.6) 
 Thighs 3 (13.6) 
 Chest 3 (13.6) 
 Everywhere 3 (13.6) 
 Other (back, abdomen, nails, fingers/toes, groin) 5 (22.7) 
Time to onset of hyperpigmentation, mo 22 
 <3 10 (45.5) 
 3-6 4 (18.2) 
 >6 6 (27.3) 
 Unsure 2 (9.1) 
Resolution of hyperpigmentation after IMiD discontinuation 11 
 Not better 2 (18.2) 
 Partially better 5 (45.5) 
 Fully resolved 4 (36.6) 
Score (1-10 scale) of distress caused by hyperpigmentation 22 
 More bothersome (7-10 of 10) 7 (31.8) 
 Less bothersome (1-6 of 10) 15 (68.2) 
 Range 1-9 

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