Cytogenetic characteristics of patients with inv(16) and those with t(8;21)
| Characteristic . | inv(16) (n = 290) . | t(8;21) (n = 247) . | Total (N = 537) . | P . |
|---|---|---|---|---|
| Presence of subclones | .52 | |||
| No | 204 (78) | 172 (75) | 376 (76) | |
| Yes | 59 (22) | 57 (25) | 118 (24) | |
| Presence of normal metaphases | .52 | |||
| No | 153 (55) | 124 (52) | 277 (57) | |
| Yes | 108 (45) | 100 (48) | 208 (43) | |
| Presence of secondary cytogenetic abnormality(s) | <.01 | |||
| No | 155 (58) | 78 (34) | 233 (47) | |
| Yes | 113 (42) | 154 (66) | 267 (53) | |
| Deletion of 7q | .17 | |||
| No | 250 (96) | 209 (93) | 459 (94) | |
| Yes | 11 (4) | 16 (7) | 27 (6) | |
| Trisomy 8 | <.01 | |||
| No | 220 (84) | 209 (93) | 529 (88) | |
| Yes | 41 (16) | 16 (7) | 57 (12) | |
| Deletion of 9q | <.01 | |||
| No | 260 (99.6) | 192 (85) | 452 (93) | |
| Yes | 1 (0.4) | 33 (15) | 34 (7) | |
| Trisomy 13 | .09 | |||
| No | 255 (98) | 224 (99.6) | 479 (99) | |
| Yes | 6 (2) | 1 (0.4) | 7 (1) | |
| Trisomy 21 | <.01 | |||
| No | 245 (94) | 225 (100) | 470 (97) | |
| Yes | 16 (6) | 0 (0) | 16 (3) | |
| Trisomy 22 | <.01 | |||
| No | 217 (83) | 225 (100) | 442 (91) | |
| Yes | 44 (17) | 0 (0) | 44 (9) | |
| Loss of X in females | <.01 | |||
| No | 123 (100) | 57 (63) | 180 (85) | |
| Yes | 0 (0) | 33 (37) | 33 (15) | |
| Loss of Y in males | <.01 | |||
| No | 120 (95) | 71 (56) | 191 (75) | |
| Yes | 7 (5) | 55 (44) | 62 (25) | |
| Other secondary abnormalities | .30 | |||
| No | 216 (83) | 177 (79) | 393 (81) | |
| Yes | 45 (17) | 47 (21) | 92 (19) | |
| Complex karyotype | .02 | |||
| No | 218 (84) | 169 (75) | 387 (80) | |
| Yes | 42 (16) | 55 (25) | 97 (20) | |
| Ploidy level | <.01 | |||
| Hypodiploidy | 7 (3) | 87 (37) | 94 (18) | |
| Pseudodiploidy | 197 (72) | 126 (54) | 323 (64) | |
| Hyperdiploidy | 68 (25) | 22 (9) | 90 (18) |
| Characteristic . | inv(16) (n = 290) . | t(8;21) (n = 247) . | Total (N = 537) . | P . |
|---|---|---|---|---|
| Presence of subclones | .52 | |||
| No | 204 (78) | 172 (75) | 376 (76) | |
| Yes | 59 (22) | 57 (25) | 118 (24) | |
| Presence of normal metaphases | .52 | |||
| No | 153 (55) | 124 (52) | 277 (57) | |
| Yes | 108 (45) | 100 (48) | 208 (43) | |
| Presence of secondary cytogenetic abnormality(s) | <.01 | |||
| No | 155 (58) | 78 (34) | 233 (47) | |
| Yes | 113 (42) | 154 (66) | 267 (53) | |
| Deletion of 7q | .17 | |||
| No | 250 (96) | 209 (93) | 459 (94) | |
| Yes | 11 (4) | 16 (7) | 27 (6) | |
| Trisomy 8 | <.01 | |||
| No | 220 (84) | 209 (93) | 529 (88) | |
| Yes | 41 (16) | 16 (7) | 57 (12) | |
| Deletion of 9q | <.01 | |||
| No | 260 (99.6) | 192 (85) | 452 (93) | |
| Yes | 1 (0.4) | 33 (15) | 34 (7) | |
| Trisomy 13 | .09 | |||
| No | 255 (98) | 224 (99.6) | 479 (99) | |
| Yes | 6 (2) | 1 (0.4) | 7 (1) | |
| Trisomy 21 | <.01 | |||
| No | 245 (94) | 225 (100) | 470 (97) | |
| Yes | 16 (6) | 0 (0) | 16 (3) | |
| Trisomy 22 | <.01 | |||
| No | 217 (83) | 225 (100) | 442 (91) | |
| Yes | 44 (17) | 0 (0) | 44 (9) | |
| Loss of X in females | <.01 | |||
| No | 123 (100) | 57 (63) | 180 (85) | |
| Yes | 0 (0) | 33 (37) | 33 (15) | |
| Loss of Y in males | <.01 | |||
| No | 120 (95) | 71 (56) | 191 (75) | |
| Yes | 7 (5) | 55 (44) | 62 (25) | |
| Other secondary abnormalities | .30 | |||
| No | 216 (83) | 177 (79) | 393 (81) | |
| Yes | 45 (17) | 47 (21) | 92 (19) | |
| Complex karyotype | .02 | |||
| No | 218 (84) | 169 (75) | 387 (80) | |
| Yes | 42 (16) | 55 (25) | 97 (20) | |
| Ploidy level | <.01 | |||
| Hypodiploidy | 7 (3) | 87 (37) | 94 (18) | |
| Pseudodiploidy | 197 (72) | 126 (54) | 323 (64) | |
| Hyperdiploidy | 68 (25) | 22 (9) | 90 (18) |
Data are expressed as the number of patients affected (percentage of study subgroups and total). Bold P values are statistically significant.