AEs leading to discontinuation of prior KI
| Intolerant AE on prior tyrosine KI . | Grade 2 (n) . | Grade 3 (n) . | Grade 4 (n) . | All grades (n) . |
|---|---|---|---|---|
| Rash | 6 | 8 | 14 | |
| Arthralgia | 3 | 5 | 1 | 9 |
| Atrial fibrillation | 5 | 2 | 1 | 8 |
| Bleeding | 1 | 3 | 4 | |
| Fatigue | 2 | 2 | 4 | |
| Anorexia/weight loss | 3 | 3 | ||
| Colitis | 1 | 2 | 3 | |
| Congestive heart failure | 1 | 1 | 1 | 3 |
| Pneumonitis | 2 | 1 | 3 | |
| Bruising | 2 | 2 | ||
| Diarrhea | 1 | 1 | 2 | |
| Hypertension | 2 | 2 | ||
| Nausea | 2 | 2 | ||
| Cough | 1 | 1 | ||
| Dizziness | 1 | 1 | ||
| Edema | 1 | 1 | ||
| Gastrointestinal toxicity | 1 | 1 | ||
| Hyperuricemia | 1 | 1 | ||
| Infection | 1 | 1 | ||
| Malaise | 1 | 1 | ||
| Mental status change | 1 | 1 | ||
| Myalgia | 1 | 1 | ||
| Pericardial effusion | 1 | 1 | ||
| Respiratory failure | 1 | 1 | ||
| Tendonitis | 1 | 1 | ||
| Brain abscess | 1 | 1 | ||
| Transaminitis | 1 | 1 | ||
| TOTAL | 39 | 28 | 6 | 73 |
| Intolerant AE on prior tyrosine KI . | Grade 2 (n) . | Grade 3 (n) . | Grade 4 (n) . | All grades (n) . |
|---|---|---|---|---|
| Rash | 6 | 8 | 14 | |
| Arthralgia | 3 | 5 | 1 | 9 |
| Atrial fibrillation | 5 | 2 | 1 | 8 |
| Bleeding | 1 | 3 | 4 | |
| Fatigue | 2 | 2 | 4 | |
| Anorexia/weight loss | 3 | 3 | ||
| Colitis | 1 | 2 | 3 | |
| Congestive heart failure | 1 | 1 | 1 | 3 |
| Pneumonitis | 2 | 1 | 3 | |
| Bruising | 2 | 2 | ||
| Diarrhea | 1 | 1 | 2 | |
| Hypertension | 2 | 2 | ||
| Nausea | 2 | 2 | ||
| Cough | 1 | 1 | ||
| Dizziness | 1 | 1 | ||
| Edema | 1 | 1 | ||
| Gastrointestinal toxicity | 1 | 1 | ||
| Hyperuricemia | 1 | 1 | ||
| Infection | 1 | 1 | ||
| Malaise | 1 | 1 | ||
| Mental status change | 1 | 1 | ||
| Myalgia | 1 | 1 | ||
| Pericardial effusion | 1 | 1 | ||
| Respiratory failure | 1 | 1 | ||
| Tendonitis | 1 | 1 | ||
| Brain abscess | 1 | 1 | ||
| Transaminitis | 1 | 1 | ||
| TOTAL | 39 | 28 | 6 | 73 |