Table 3. Multivariate Cox proportional... | American Society of Hematology

Table 3.

Multivariate Cox proportional hazards regression analyses focusing on the MRD^2nd

Variables	CIR				RFS				OS
Variables	HR	Lower	Upper	P	HR	Lower	Upper	P	HR	Lower	Upper	P
Age*	0.995	0.984	1.007	.425	0.997	0.986	1.007	.561	1.012	1.000	1.024	.051
WBC counts,* ×10³/μL	1.004	1.001	1.007	.004	1.003	1.001	1.006	.011	1.003	1.000	1.006	.044
ELN risk stratification
Intermediate vs favorable	1.990	1.322	2.995	.001	2.034	1.388	2.980	<.001	2.478	1.603	3.831	<.001
Adverse vs favorable	2.361	1.477	3.773	<.001	2.416	1.564	3.734	<.001	2.712	1.676	4.387	<.001
Number of induction chemotherapy cycles†	1.500	1.002	2.244	.049	1.497	1.032	2.172	.034	1.465	0.984	2.185	.060
HSCT at CR1‡	0.202	0.116	0.53	<.001	0.286	0.180	0.455	<.001	0.578	0.362	0.922	.021
MRD^2nd§	2.206	1.525	3.190	<.001	2.142	1.520	3.018	<.001	1.649	1.133	2.399	.009

Variables	CIR				RFS				OS
Variables	HR	Lower	Upper	P	HR	Lower	Upper	P	HR	Lower	Upper	P
Age*	0.995	0.984	1.007	.425	0.997	0.986	1.007	.561	1.012	1.000	1.024	.051
WBC counts,* ×10³/μL	1.004	1.001	1.007	.004	1.003	1.001	1.006	.011	1.003	1.000	1.006	.044
ELN risk stratification
Intermediate vs favorable	1.990	1.322	2.995	.001	2.034	1.388	2.980	<.001	2.478	1.603	3.831	<.001
Adverse vs favorable	2.361	1.477	3.773	<.001	2.416	1.564	3.734	<.001	2.712	1.676	4.387	<.001
Number of induction chemotherapy cycles†	1.500	1.002	2.244	.049	1.497	1.032	2.172	.034	1.465	0.984	2.185	.060
HSCT at CR1‡	0.202	0.116	0.53	<.001	0.286	0.180	0.455	<.001	0.578	0.362	0.922	.021
MRD^2nd§	2.206	1.525	3.190	<.001	2.142	1.520	3.018	<.001	1.649	1.133	2.399	.009

Continuous variables.

Two cycles vs 1 cycle.

HSCT at CR1 vs HSCT at other disease status or without HSCT.

MRD positivity vs negativity at the second time point. The MRD positivity and negativity are evaluated after excluding DTA mutations.