Multivariate analysis of the cumulative incidence of relapse using a Fine and Gray model
| Parameters . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|
| FBXW7/NOTCH1 | 1.2 | 0.25-5.5 | .84 |
| PTEN | 1.8 | 0.20-15.7 | .61 |
| KMT2D | 1.4 | 0.17-11.7 | .76 |
| LOH6q | 3.2 | 1.0-9.9 | .04 |
| Interaction: NOTCH1 or FBXW7 with PTEN | 0.4 | 0.04-5.7 | .53 |
| Interaction: NOTCH1 or FBXW7 with KMT2D | 0.86 | 0.06-11.8 | .90 |
| Interaction: NOTCH1 or FBXW7 with PTEN or KMT2D | 13.5 | 1.1-170.5 | .04 |
| Parameters . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|
| FBXW7/NOTCH1 | 1.2 | 0.25-5.5 | .84 |
| PTEN | 1.8 | 0.20-15.7 | .61 |
| KMT2D | 1.4 | 0.17-11.7 | .76 |
| LOH6q | 3.2 | 1.0-9.9 | .04 |
| Interaction: NOTCH1 or FBXW7 with PTEN | 0.4 | 0.04-5.7 | .53 |
| Interaction: NOTCH1 or FBXW7 with KMT2D | 0.86 | 0.06-11.8 | .90 |
| Interaction: NOTCH1 or FBXW7 with PTEN or KMT2D | 13.5 | 1.1-170.5 | .04 |
In a multivariate analysis with the factors NOTCH1mut or FBXW7mut, KMT2D, PTEN, LOH6q mutations and interaction terms between PTEN, KMT2D, PTEN or KMT2D and NOTCH1/FBXW7 (both WT); only LOH6q and the interaction term with PTEN or KMT2D were significant.