Selected grade 3 to 5 toxicities in induction-1, induction-2, and in each cycle of early consolidation
| . | Induction-1 (%) . | Induction-2 (%) . | C-1 (%) . | C-2 (%) . | C-3 (%) . |
|---|---|---|---|---|---|
| Neutropenia | 306/332 (92) | 80/82 (98) | 51/207 (25) | 133/193 (69) | 19/173 (11) |
| Days, median (min; max) | 20 (1; 45) | 19 (3; 60) | 4 (1; 33) | 4 (1; 13) | 4 (1; 10) |
| Thrombocytopenia | 188/326 (58) | 78/82 (95) | 16/206 (8) | 77/193 (40) | 4/173 (2) |
| Days, median (min; max) | 10 (1; 46) | 12 (2; 50) | 2 (1; 33) | 2 (1; 11) | 2 (1; 2) |
| Infection | 175/333 (53)* | 71/84 (85)# | 18/213 (8)†† | 39/198 (20) | 8/180 (4) |
| Hypersensitivity | 3/330 (1) | 0 | 3/209 (1) | 5/198 (3) | 7/179 (4) |
| Neurologic | 19/330 (6)† | 2/82 (2) | 3/211 (1) | 4/199 (2) | 3/180 (2) |
| Hepatic | 88/328 (27)‡ | 7/81 (9) | 15/211 (7) | 4/199 (2) | 9/180 (5) |
| Renal | 4/331 (1) | 0 | 11/211 (5) | 0 | 2/178 (1) |
| Digestive | 12/323 (4)§ | 10/82 (12)** | 3/212 (1) | 1/198 (0.5) | 0 |
| Mucositis | 16/323 (5) | 7/81 (9) | 3/213 (1) | 1/200 (0.5) | 1/179 (1) |
| Coagulation disorders | 35/329 (11) | 0 | 2/208 (1) | 1/196 (0.5) | 0 |
| Vascular | 28/329 (9) | 4/82 (5) | 2/208 (1) | 1/196 (0.5) | 0 |
| Metabolic | 13/329 (4) | 0 | 2/208 (1) | 1/196 (0.5) | 2/176 (1) |
| Cardiac | 3/329 (1)‖ | 0 | 0 | 0 | 0 |
| Hemorrhagic | 2/329 (1)¶ | 0 | 0 | 0 | 0 |
| Endocrine | 1/329 (0.3) | 0 | 1/208 (0.5) | 0 | 0 |
| Musculoskeletal | 3/329 (1) | 0 | 0 | 1/196 (0.5) | 1/176 (1) |
| Psychiatric | 0 | 0 | 0 | 1/196 (0.5) | 0 |
| . | Induction-1 (%) . | Induction-2 (%) . | C-1 (%) . | C-2 (%) . | C-3 (%) . |
|---|---|---|---|---|---|
| Neutropenia | 306/332 (92) | 80/82 (98) | 51/207 (25) | 133/193 (69) | 19/173 (11) |
| Days, median (min; max) | 20 (1; 45) | 19 (3; 60) | 4 (1; 33) | 4 (1; 13) | 4 (1; 10) |
| Thrombocytopenia | 188/326 (58) | 78/82 (95) | 16/206 (8) | 77/193 (40) | 4/173 (2) |
| Days, median (min; max) | 10 (1; 46) | 12 (2; 50) | 2 (1; 33) | 2 (1; 11) | 2 (1; 2) |
| Infection | 175/333 (53)* | 71/84 (85)# | 18/213 (8)†† | 39/198 (20) | 8/180 (4) |
| Hypersensitivity | 3/330 (1) | 0 | 3/209 (1) | 5/198 (3) | 7/179 (4) |
| Neurologic | 19/330 (6)† | 2/82 (2) | 3/211 (1) | 4/199 (2) | 3/180 (2) |
| Hepatic | 88/328 (27)‡ | 7/81 (9) | 15/211 (7) | 4/199 (2) | 9/180 (5) |
| Renal | 4/331 (1) | 0 | 11/211 (5) | 0 | 2/178 (1) |
| Digestive | 12/323 (4)§ | 10/82 (12)** | 3/212 (1) | 1/198 (0.5) | 0 |
| Mucositis | 16/323 (5) | 7/81 (9) | 3/213 (1) | 1/200 (0.5) | 1/179 (1) |
| Coagulation disorders | 35/329 (11) | 0 | 2/208 (1) | 1/196 (0.5) | 0 |
| Vascular | 28/329 (9) | 4/82 (5) | 2/208 (1) | 1/196 (0.5) | 0 |
| Metabolic | 13/329 (4) | 0 | 2/208 (1) | 1/196 (0.5) | 2/176 (1) |
| Cardiac | 3/329 (1)‖ | 0 | 0 | 0 | 0 |
| Hemorrhagic | 2/329 (1)¶ | 0 | 0 | 0 | 0 |
| Endocrine | 1/329 (0.3) | 0 | 1/208 (0.5) | 0 | 0 |
| Musculoskeletal | 3/329 (1) | 0 | 0 | 1/196 (0.5) | 1/176 (1) |
| Psychiatric | 0 | 0 | 0 | 1/196 (0.5) | 0 |