Pathological features of CLL patients and IL-9 mRNA levels in the respective leukemic cells
| . | mRNA (threshold = 0.16 ± 0.38 2−dCt) . | |
|---|---|---|
| IL-9 below threshold . | IL-9 above threshold . | |
| (i) CLL patients, n | 26 | 26 |
| (ii) UM-CLL patients, % | 19.2 | 57.7 |
| IL-9 mRNA | 0.03 ± 0.05 | 0.61 ± 0.34*** |
| p66Shc mRNA | 0.27 ± 0.09 | 0.08 ± 0.07*** |
| (iii) LN > 1.5 cm, % of patients with characteristic | 65.4 | 80.8 |
| (iv) Spleen infiltration (>13 cm), % of patients with characteristic | 23.1 | 50.0 |
| (v) Liver infiltration (>1 cm under arch), % of patients with characteristic | 11.5 | 26.9 |
| . | mRNA (threshold = 0.16 ± 0.38 2−dCt) . | |
|---|---|---|
| IL-9 below threshold . | IL-9 above threshold . | |
| (i) CLL patients, n | 26 | 26 |
| (ii) UM-CLL patients, % | 19.2 | 57.7 |
| IL-9 mRNA | 0.03 ± 0.05 | 0.61 ± 0.34*** |
| p66Shc mRNA | 0.27 ± 0.09 | 0.08 ± 0.07*** |
| (iii) LN > 1.5 cm, % of patients with characteristic | 65.4 | 80.8 |
| (iv) Spleen infiltration (>13 cm), % of patients with characteristic | 23.1 | 50.0 |
| (v) Liver infiltration (>1 cm under arch), % of patients with characteristic | 11.5 | 26.9 |
CLL patients were grouped as “above threshold” or “below threshold,” corresponding to the median 2−dCt IL-9 mRNA. Organ infiltration was classified according to the International Workshop on Chronic Lymphocytic Leukemia.14
P ≤ .001, Mann-Whitney rank-sum test.