Summary of doses of systemic or nanoparticle encapsulated S63845 administered as a single agent or in combination with venetoclax
| S63845 . | . | . | |||
|---|---|---|---|---|---|
| S63845 dose (mg/kg) . | S63845 administration format . | No. of S63845 doses per week . | Total S63845 dose in 2 weeks (mg/kg) . | Administration of venetoclax 100 mg/kg 5 times per week . | Number of mice with measurable tumors on day 75 . |
| 25 | Free drug | 5 | 250 | No | NA |
| 12.5 | Free drug | 3 | 75 | No | NA |
| 12.5 | NP | 3 | 75 | No | NA |
| 25 | Free drug | 5 | 250 | Yes | 0 of 4 |
| 12.5 | Free drug | 3 | 75 | Yes | 2 of 4 |
| 12.5 | NP | 3 | 75 | Yes | 0 of 4 |
| S63845 . | . | . | |||
|---|---|---|---|---|---|
| S63845 dose (mg/kg) . | S63845 administration format . | No. of S63845 doses per week . | Total S63845 dose in 2 weeks (mg/kg) . | Administration of venetoclax 100 mg/kg 5 times per week . | Number of mice with measurable tumors on day 75 . |
| 25 | Free drug | 5 | 250 | No | NA |
| 12.5 | Free drug | 3 | 75 | No | NA |
| 12.5 | NP | 3 | 75 | No | NA |
| 25 | Free drug | 5 | 250 | Yes | 0 of 4 |
| 12.5 | Free drug | 3 | 75 | Yes | 2 of 4 |
| 12.5 | NP | 3 | 75 | Yes | 0 of 4 |
NA, not applicable.