Summary of doses of S63845 used in combination with venetoclax at 100 mg/kg administered orally 5 times per week in an SU-DHL-6 mouse xenograft model
| S63845 IV dose (mg/kg) . | No. of doses per week . | Total dose in 2 weeks (mg/kg) . | No. of mice with measureable tumors on day 75 . |
|---|---|---|---|
| 25 | 5 | 250 | 0/5 |
| 25 | 3 | 150 | 3/5 |
| 12.5 | 5 | 125 | 2/5 |
| 25 | 2 | 100 | 3/5 |
| S63845 IV dose (mg/kg) . | No. of doses per week . | Total dose in 2 weeks (mg/kg) . | No. of mice with measureable tumors on day 75 . |
|---|---|---|---|
| 25 | 5 | 250 | 0/5 |
| 25 | 3 | 150 | 3/5 |
| 12.5 | 5 | 125 | 2/5 |
| 25 | 2 | 100 | 3/5 |