Rurioctocog alfa pegol prophylaxis consumption (12-mo study period; FAS and PPAS)
| . | FAS (N = 115) . | PPAS (N = 95) . | ||
|---|---|---|---|---|
| FVIII trough level 1% to 3% (n = 57) . | FVIII trough level 8% to 12% (n = 58) . | FVIII trough level 1% to 3% (n = 52) . | FVIII trough level 8% to 12% (n = 43) . | |
| Number of prophylactic infusions per week | ||||
| Mean (SD) | 2.3 (0.6) | 3.6 (1.2) | 2.3 (0.6) | 3.8 (1.2) |
| Median (Q1 to Q3) | 2.0 (2.0-2.3) | 3.4 (3.1-3.6) | 2.0 (2.0-2.3) | 3.5 (3.3-4.3) |
| Range | 1.5-3.5 | 1.6-6.8 | 1.5-3.5 | 1.6-6.8 |
| Number of prophylactic infusions per year | ||||
| Mean (SD) | 117.9 (30.3) | 189.7 (61.6) | 117.8 (30.0) | 198.6 (64.7) |
| Median (Q1 to Q3) | 104.4 (102.3-121.4) | 179.4 (162.6-188.5) | 104.4 (102.3-121.4) | 181.6 (171.6-222.8) |
| Range | 80.3-181.6 | 83.3-356.2 | 80.3-181.6 | 83.3-356.2 |
| Prophylactic dose per infusion (IU/kg) | ||||
| Mean (SD) | 33.0 (12.6) | 40.3 (14.2) | 33.6 (13.0) | 37.7 (13.3) |
| Median (Q1 to Q3) | 30.3 (23.3-40.3) | 38.4 (26.8-51.6) | 31.7 (23.1-41.7) | 34.2 (26.1-48.4) |
| Range | 15.2-65.2 | 16.2-73.6 | 15.2-65.2 | 18.8-73.6 |
| Prophylactic dose per week (IU/kg) | ||||
| Mean (SD) | 74.0 (31.8) | 143.3 (56.2) | 75.3 (32.5) | 142.4 (60.0) |
| Median (Q1 to Q3) | 66.2 (51.3-96.3) | 143.6 (91.4-189.8) | 67.0 (51.5-96.6) | 140.2 (89.3-191.1) |
| Range | 30.9-163.6 | 39.0-253.3 | 30.9-163.6 | 39.0-253.3 |
| Prophylactic dose per year (IU/kg) | ||||
| Mean (SD) | 3860.8 (1658.0) | 7478.2 (2934.5) | 3930.0 (1695.0) | 7432.6 (3127.8) |
| Median (Q1 to Q3) | 3453.9 (2678.9-5022.4) | 7490.2 (4771.6-9903.3) | 3497.2 (2688.9-5039.5) | 7316.2 (4659.7-9972.6) |
| Range | 1614.3-8535.3 | 2036.3-13 215.5 | 1614.3-8535.3 | 2036.3-13 215.5 |
| . | FAS (N = 115) . | PPAS (N = 95) . | ||
|---|---|---|---|---|
| FVIII trough level 1% to 3% (n = 57) . | FVIII trough level 8% to 12% (n = 58) . | FVIII trough level 1% to 3% (n = 52) . | FVIII trough level 8% to 12% (n = 43) . | |
| Number of prophylactic infusions per week | ||||
| Mean (SD) | 2.3 (0.6) | 3.6 (1.2) | 2.3 (0.6) | 3.8 (1.2) |
| Median (Q1 to Q3) | 2.0 (2.0-2.3) | 3.4 (3.1-3.6) | 2.0 (2.0-2.3) | 3.5 (3.3-4.3) |
| Range | 1.5-3.5 | 1.6-6.8 | 1.5-3.5 | 1.6-6.8 |
| Number of prophylactic infusions per year | ||||
| Mean (SD) | 117.9 (30.3) | 189.7 (61.6) | 117.8 (30.0) | 198.6 (64.7) |
| Median (Q1 to Q3) | 104.4 (102.3-121.4) | 179.4 (162.6-188.5) | 104.4 (102.3-121.4) | 181.6 (171.6-222.8) |
| Range | 80.3-181.6 | 83.3-356.2 | 80.3-181.6 | 83.3-356.2 |
| Prophylactic dose per infusion (IU/kg) | ||||
| Mean (SD) | 33.0 (12.6) | 40.3 (14.2) | 33.6 (13.0) | 37.7 (13.3) |
| Median (Q1 to Q3) | 30.3 (23.3-40.3) | 38.4 (26.8-51.6) | 31.7 (23.1-41.7) | 34.2 (26.1-48.4) |
| Range | 15.2-65.2 | 16.2-73.6 | 15.2-65.2 | 18.8-73.6 |
| Prophylactic dose per week (IU/kg) | ||||
| Mean (SD) | 74.0 (31.8) | 143.3 (56.2) | 75.3 (32.5) | 142.4 (60.0) |
| Median (Q1 to Q3) | 66.2 (51.3-96.3) | 143.6 (91.4-189.8) | 67.0 (51.5-96.6) | 140.2 (89.3-191.1) |
| Range | 30.9-163.6 | 39.0-253.3 | 30.9-163.6 | 39.0-253.3 |
| Prophylactic dose per year (IU/kg) | ||||
| Mean (SD) | 3860.8 (1658.0) | 7478.2 (2934.5) | 3930.0 (1695.0) | 7432.6 (3127.8) |
| Median (Q1 to Q3) | 3453.9 (2678.9-5022.4) | 7490.2 (4771.6-9903.3) | 3497.2 (2688.9-5039.5) | 7316.2 (4659.7-9972.6) |
| Range | 1614.3-8535.3 | 2036.3-13 215.5 | 1614.3-8535.3 | 2036.3-13 215.5 |