Table 1.
Primary prophylaxis for hospitalized medical patients with cancer 
 Thromboprophylaxis vs no thromboprophylaxis 
 LMWH vs UFH 
 Combination of methods vs pharmacological thromboprophylaxis 
 Mechanical vs pharmacological thromboprophylaxis 
 Continuation of thromboprophylaxis at home vs discontinuation at time of discharge 
Primary prophylaxis for patients with cancer undergoing surgery 
 Pharmacological vs mechanical thromboprophylaxis 
 Combination of pharmacologic and mechanical prophylaxis vs mechanical thromboprophylaxis alone 
 Combination of pharmacologic and mechanical prophylaxis vs pharmacological thromboprophylaxis alone 
 LMWH vs UFH 
 Fondaparinux vs LMWH 
 Preoperative thromboprophylaxis vs immediate postoperative thromboprophylaxis 
 Extended (continue at home) vs limited (7-10 d; discontinue at the time of discharge) 
Primary prophylaxis for ambulatory patients with cancer receiving systemic therapy 
 Parenteral thromboprophylaxis vs no thromboprophylaxis 
 VKA thromboprophylaxis vs no thromboprophylaxis 
 DOAC thromboprophylaxis vs no thromboprophylaxis 
 Low-dose ASA thromboprophylaxis vs fixed-dose VKA 
 Low-dose ASA vs LMWH 
Primary prophylaxis for patients with cancer with CVC 
 Parenteral thromboprophylaxis vs no thromboprophylaxis 
 Oral thromboprophylaxis vs no thromboprophylaxis 
Initial treatment (within first week) for patients with cancer 
 LMWH vs UFH 
 Fondaparinux vs LMWH 
 DOAC vs LMWH 
Short-term treatment for patients with active cancer (initial 3-6 mo) 
 LMWH vs VKA 
 DOAC vs VKA 
 DOAC vs LMWH 
 Short-term treatment (3-6 mo) vs observation for patients with cancer and incidental PE 
 Short-term treatment (3-6 mo) vs observation for patients with cancer and SSPE 
 Short-term treatment (3-6 mo) vs observation for patients with cancer and visceral/splanchnic vein thrombosis 
 Keeping CVC vs removing CVC 
 Increasing dose to supratherapeutic levels vs continuing with standard therapeutic dose 
 Adding an IVC filter vs not for patients with cancer and recurrent VTEs, despite therapeutic anticoagulation treatment 
Long-term treatment (>6 mo) for patients with active cancer and VTE 
 Long-term anticoagulation (>6 mo) vs short-term anticoagulation (3-6 mo) 
 Continuing indefinite anticoagulation vs stopping after completion of a definitive period of anticoagulation 
 DOAC vs LMWH for long-term anticoagulation 
Primary prophylaxis for hospitalized medical patients with cancer 
 Thromboprophylaxis vs no thromboprophylaxis 
 LMWH vs UFH 
 Combination of methods vs pharmacological thromboprophylaxis 
 Mechanical vs pharmacological thromboprophylaxis 
 Continuation of thromboprophylaxis at home vs discontinuation at time of discharge 
Primary prophylaxis for patients with cancer undergoing surgery 
 Pharmacological vs mechanical thromboprophylaxis 
 Combination of pharmacologic and mechanical prophylaxis vs mechanical thromboprophylaxis alone 
 Combination of pharmacologic and mechanical prophylaxis vs pharmacological thromboprophylaxis alone 
 LMWH vs UFH 
 Fondaparinux vs LMWH 
 Preoperative thromboprophylaxis vs immediate postoperative thromboprophylaxis 
 Extended (continue at home) vs limited (7-10 d; discontinue at the time of discharge) 
Primary prophylaxis for ambulatory patients with cancer receiving systemic therapy 
 Parenteral thromboprophylaxis vs no thromboprophylaxis 
 VKA thromboprophylaxis vs no thromboprophylaxis 
 DOAC thromboprophylaxis vs no thromboprophylaxis 
 Low-dose ASA thromboprophylaxis vs fixed-dose VKA 
 Low-dose ASA vs LMWH 
Primary prophylaxis for patients with cancer with CVC 
 Parenteral thromboprophylaxis vs no thromboprophylaxis 
 Oral thromboprophylaxis vs no thromboprophylaxis 
Initial treatment (within first week) for patients with cancer 
 LMWH vs UFH 
 Fondaparinux vs LMWH 
 DOAC vs LMWH 
Short-term treatment for patients with active cancer (initial 3-6 mo) 
 LMWH vs VKA 
 DOAC vs VKA 
 DOAC vs LMWH 
 Short-term treatment (3-6 mo) vs observation for patients with cancer and incidental PE 
 Short-term treatment (3-6 mo) vs observation for patients with cancer and SSPE 
 Short-term treatment (3-6 mo) vs observation for patients with cancer and visceral/splanchnic vein thrombosis 
 Keeping CVC vs removing CVC 
 Increasing dose to supratherapeutic levels vs continuing with standard therapeutic dose 
 Adding an IVC filter vs not for patients with cancer and recurrent VTEs, despite therapeutic anticoagulation treatment 
Long-term treatment (>6 mo) for patients with active cancer and VTE 
 Long-term anticoagulation (>6 mo) vs short-term anticoagulation (3-6 mo) 
 Continuing indefinite anticoagulation vs stopping after completion of a definitive period of anticoagulation 
 DOAC vs LMWH for long-term anticoagulation 

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