Top SNPs associated with osteonecrosis across the 3 cohorts
| . | . | . | . | AALL0434 (55 cases, 654 controls) . | UK BioBank (542 cases, 391 041 controls) . | AALL0232 (250 cases, 2035 controls) . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbSNP . | Chr: pos . | Risk allele . | Alternate allele . | RAF . | HR . | P . | RAF . | HR . | P . | RAF . | HR . | P . | ALL meta P . |
| rs2973215 | 4:37438368 | T | A | 0.799 | 4.1 | 3.29 × 10−5 | 0.812 | 1.37 | 5.68 × 10−5 | 0.791 | 1.57 | .000233 | 3.05 × 10−8 |
| rs1479756 | 4:37437061 | A | G | 0.774 | 4.06 | 1.67 × 10−5 | 0.784 | 1.32 | .000175 | 0.764 | 1.48 | .000583 | 4.35 × 10−8 |
| . | . | . | . | AALL0434 (55 cases, 654 controls) . | UK BioBank (542 cases, 391 041 controls) . | AALL0232 (250 cases, 2035 controls) . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbSNP . | Chr: pos . | Risk allele . | Alternate allele . | RAF . | HR . | P . | RAF . | HR . | P . | RAF . | HR . | P . | ALL meta P . |
| rs2973215 | 4:37438368 | T | A | 0.799 | 4.1 | 3.29 × 10−5 | 0.812 | 1.37 | 5.68 × 10−5 | 0.791 | 1.57 | .000233 | 3.05 × 10−8 |
| rs1479756 | 4:37437061 | A | G | 0.774 | 4.06 | 1.67 × 10−5 | 0.784 | 1.32 | .000175 | 0.764 | 1.48 | .000583 | 4.35 × 10−8 |
Chr, chromosome; dbSNP, Single Nucleotide Polymorphism database; HR, hazard ratio; pos, Genome Reference Consortium Human Build 37 position; RAF, risk allele frequency.