Characteristics of patients and controls
| Characteristic . | CTEPH patients (n = 141) . | Controls (n = 60) . |
|---|---|---|
| Mean age, y | 58.7 ± 13.5 | 61.0 ± 6.7 |
| Sex | ||
| Male | 58 | 21 |
| Female | 83 | 39 |
| Body-mass-index, kg/m2 | 26.6 (24.0-30.7) | 25.3 (22.6-27.9)* |
| WHO functional class | ||
| I | 5 | 60 |
| II | 23 | 0 |
| III | 84 | 0 |
| IV | 29 | 0 |
| Hemodynamic parameters | ||
| Pulmonary arterial pressure, mmHg | ||
| Systolic | 82.0 (63.0-101.7) | NA |
| Diastolic | 27.0 (20.0-35.0) | NA |
| Mean | 47.0 (35.0-55.7) | NA |
| Mean wedge | 9.0 (7.0-13.0) | NA |
| Pulmonary vascular resistance, dynes/s/cm−5 | 654 (333-894) | NA |
| Arterial saturation, % | 91.0 (86.0-93.2) | NA |
| Cardiac output, L/min | 4.6 (3.9-5.5) | NA |
| Cardiac index, L/min/m2 | 2.4 (2.1-2.8) | NA |
| Laboratory parameters | ||
| Leukocytes, G/L | 6.7 (5.7-8.3) | 5.8 (5.0-7.0)* |
| Neutrophils, G/L | 4.5 (3.5-5.3) | 3.4 (2.8-4.0)* |
| Fibrinogen, mg/dL | 360.0 (310.5-436.5) | NA |
| C-reactive protein, mg/dL | 0.3 (0.1-0.8) | 0.4 (0.1-1.0) |
| Serum amyloid A, mg/L | 8.3 (5.9-14.1) | NA |
| NT-proBNP, pg/mL | 1099.0 (230.4-2694.0) | NA |
| Lower extremity conditions | ||
| Previous DVT, lower leg trauma, surgeries, wound infections, or venous ulcers | 73 | 0 |
| Characteristic . | CTEPH patients (n = 141) . | Controls (n = 60) . |
|---|---|---|
| Mean age, y | 58.7 ± 13.5 | 61.0 ± 6.7 |
| Sex | ||
| Male | 58 | 21 |
| Female | 83 | 39 |
| Body-mass-index, kg/m2 | 26.6 (24.0-30.7) | 25.3 (22.6-27.9)* |
| WHO functional class | ||
| I | 5 | 60 |
| II | 23 | 0 |
| III | 84 | 0 |
| IV | 29 | 0 |
| Hemodynamic parameters | ||
| Pulmonary arterial pressure, mmHg | ||
| Systolic | 82.0 (63.0-101.7) | NA |
| Diastolic | 27.0 (20.0-35.0) | NA |
| Mean | 47.0 (35.0-55.7) | NA |
| Mean wedge | 9.0 (7.0-13.0) | NA |
| Pulmonary vascular resistance, dynes/s/cm−5 | 654 (333-894) | NA |
| Arterial saturation, % | 91.0 (86.0-93.2) | NA |
| Cardiac output, L/min | 4.6 (3.9-5.5) | NA |
| Cardiac index, L/min/m2 | 2.4 (2.1-2.8) | NA |
| Laboratory parameters | ||
| Leukocytes, G/L | 6.7 (5.7-8.3) | 5.8 (5.0-7.0)* |
| Neutrophils, G/L | 4.5 (3.5-5.3) | 3.4 (2.8-4.0)* |
| Fibrinogen, mg/dL | 360.0 (310.5-436.5) | NA |
| C-reactive protein, mg/dL | 0.3 (0.1-0.8) | 0.4 (0.1-1.0) |
| Serum amyloid A, mg/L | 8.3 (5.9-14.1) | NA |
| NT-proBNP, pg/mL | 1099.0 (230.4-2694.0) | NA |
| Lower extremity conditions | ||
| Previous DVT, lower leg trauma, surgeries, wound infections, or venous ulcers | 73 | 0 |
Data are represented as no., mean ± standard deviation, or median (interquartile range).
NA, not available; NT-proBNP, N-terminal probrain natriuretic peptide; WHO, World Health Organization.
Descriptive P < .05 (derived from Mann-Whitney U test).