Characteristics of patients with discordant PEA-SRA results
| Patient n . | Age, y . | Sex . | 4Ts score . | Thrombosis* . | PEA . | SRA . | ELISA OD . | HIT diagnosis . | |
|---|---|---|---|---|---|---|---|---|---|
| Predefined† . | Full review‡ . | ||||||||
| PEA+/SRA− | |||||||||
| 1 | 37 | Male | 7 | Yes | 39 | 1 | 1.27 | Positive | Positive |
| 2 | 78 | Male | 7 | Yes | 46 | 5 | 0.31 | Indeterminate | Positive |
| 3 | 63 | Female | 5 | Maybe | 61 | 4 | 1.14 | Indeterminate | Positive |
| 4 | 55 | Male | 5 | No | 93 | 4 | 1.99 | Indeterminate | Positive |
| 5 | 60 | Male | 4 | No | 50 | 17 | 0.36 | Negative | Positive |
| 6 | 51 | Male | 5 | Yes | 42 | 0 | 0.61 | Negative | Negative |
| 7 | 60 | Male | 3 | Yes | 61 | 1 | 0.08 | Negative | Negative |
| 8 | 57 | Male | 3 | No | 104 | 0 | 0.07 | Negative | Negative |
| 9 | 69 | Female | 2 | No | 73 | 2 | 0.05 | Negative | Negative |
| 10 | 62 | Male | 1 | No | 54 | 1 | 0.11 | Negative | Negative |
| SRA+/PEA− | |||||||||
| 1 | 79 | Male | 6 | Yes | 19 | 32 | 1.33 | Positive | Positive |
| 2 | 48 | Female | 6 | Yes | 24 | 87 | 1.29 | Positive | Positive |
| 3 | 68 | Female | 5 | No | 8 | 66 | 1.88 | Indeterminate | Positive |
| 4 | 27 | Female | 4 | Maybe | −1 | 32 | 0.04 | Negative | Negative |
| 5 | 66 | Male | 3 | No | 5 | 57 | 1.91 | Negative | Negative |
| 6 | 74 | Female | 1 | No | 1 | 81 | 0.08 | Negative | Negative |
| 7 | 75 | Female | 0 | No | 18 | 25 | 0.08 | Negative | Negative |
| 8 | 60 | Female | 0 | No | 11 | 24 | 0.08 | Negative | Negative |
| Patient n . | Age, y . | Sex . | 4Ts score . | Thrombosis* . | PEA . | SRA . | ELISA OD . | HIT diagnosis . | |
|---|---|---|---|---|---|---|---|---|---|
| Predefined† . | Full review‡ . | ||||||||
| PEA+/SRA− | |||||||||
| 1 | 37 | Male | 7 | Yes | 39 | 1 | 1.27 | Positive | Positive |
| 2 | 78 | Male | 7 | Yes | 46 | 5 | 0.31 | Indeterminate | Positive |
| 3 | 63 | Female | 5 | Maybe | 61 | 4 | 1.14 | Indeterminate | Positive |
| 4 | 55 | Male | 5 | No | 93 | 4 | 1.99 | Indeterminate | Positive |
| 5 | 60 | Male | 4 | No | 50 | 17 | 0.36 | Negative | Positive |
| 6 | 51 | Male | 5 | Yes | 42 | 0 | 0.61 | Negative | Negative |
| 7 | 60 | Male | 3 | Yes | 61 | 1 | 0.08 | Negative | Negative |
| 8 | 57 | Male | 3 | No | 104 | 0 | 0.07 | Negative | Negative |
| 9 | 69 | Female | 2 | No | 73 | 2 | 0.05 | Negative | Negative |
| 10 | 62 | Male | 1 | No | 54 | 1 | 0.11 | Negative | Negative |
| SRA+/PEA− | |||||||||
| 1 | 79 | Male | 6 | Yes | 19 | 32 | 1.33 | Positive | Positive |
| 2 | 48 | Female | 6 | Yes | 24 | 87 | 1.29 | Positive | Positive |
| 3 | 68 | Female | 5 | No | 8 | 66 | 1.88 | Indeterminate | Positive |
| 4 | 27 | Female | 4 | Maybe | −1 | 32 | 0.04 | Negative | Negative |
| 5 | 66 | Male | 3 | No | 5 | 57 | 1.91 | Negative | Negative |
| 6 | 74 | Female | 1 | No | 1 | 81 | 0.08 | Negative | Negative |
| 7 | 75 | Female | 0 | No | 18 | 25 | 0.08 | Negative | Negative |
| 8 | 60 | Female | 0 | No | 11 | 24 | 0.08 | Negative | Negative |
OD, optical density.
Yes, maybe, and no for thrombosis correspond to 4Ts scores of 2, 1, and 0, respectively, for thrombosis.
Predefined criteria included ELISA OD, and 4Ts scores calculated at the time of HIT suspicion (Table 1).
HIT was adjudicated based on integrating 4Ts score calculated at the time of HIT suspicion as well as follow up information such as platelet trending upon heparin cessation and upon heparin reexposure (if reexposure occurred).