Table 2. Mutation profile of TN patients... | American Society of Hematology

Table 2.

Mutation profile of TN patients identified as having somatic or germline mutations

Sex	Age at diagnosis, y	Gene	VAF, %	Treatment	Platelet count, ×10⁹/L
Male	45	MPL W515R	5	HC	457
Male	14	MPL R537W	2	Nil	521
Female	19	MPL P453R*	52	IFN	471
Male	26	MPL S505N*	52	Nil	1024
Male	55	MPL S505N*	52	HC	466
Female	38	MPL		Nil	1053
		W5151G	10
		and W515S	10
Female	45	JAK2V617F	2	HC	325
Female	52	JAK2V617F	4	Nil	437
Female	36	JAK2V617F	8	HC	310
Female	69	JAK2V617F	2	HC	416

Sex	Age at diagnosis, y	Gene	VAF, %	Treatment	Platelet count, ×10⁹/L
Male	45	MPL W515R	5	HC	457
Male	14	MPL R537W	2	Nil	521
Female	19	MPL P453R*	52	IFN	471
Male	26	MPL S505N*	52	Nil	1024
Male	55	MPL S505N*	52	HC	466
Female	38	MPL		Nil	1053
		W5151G	10
		and W515S	10
Female	45	JAK2V617F	2	HC	325
Female	52	JAK2V617F	4	Nil	437
Female	36	JAK2V617F	8	HC	310
Female	69	JAK2V617F	2	HC	416

HC, hydroxycarbamide; IFN, interferon; Nil, no treatment; VAF, variant allele frequency.

*Germline mutations.