Table 3.

Molecular predictors of OS

GenotypeNo. of patientsMedian OS, moUnivariable analysisMultivariable analysis
HRPHR95% CIP
Total cohort 247 15      
NGS result   0.46 .02* 1.34 0.54-3.33 .52 
 No mutation 28 24      
 ≥1 mutation 213 14.1      
No. of mutations    .005* 1.22 1.03-1.44 .02* 
TET2   0.89 .67    
 Mut 41 16.1      
 WT 188 14.4      
ASXL1   0.84 .49    
 Mut 47 18.6      
 WT 200 14.4      
TET2-mut/ASXL1-wt and TP53-wt   0.51 .13    
 Present 21 16.1      
 Other 218 14.4      
DNMT3A   1.37 .24    
 Mut 35 11.4      
 WT 193 15.5      
EZH2   2.83 <.001* 2.41 1.03-5.64 .04* 
 Mut 15 9.9      
 WT 232 16.1      
DNA methylation mutation   0.96 .83    
 Mut 79 14.2      
 WT 148 14.4      
Epigenetic regulation mutation   1.04 .82    
 Mut 120 14.2      
 WT 115 15.5      
SF3B1   0.77 .57    
 Mut 13 18.5      
 WT 217 14.4      
Any spliceosome   0.68 .07 1.06 0.58-1.95 .84 
 Mut 77 19.1      
 WT 152 13.1      
RUNX1   1.09 .78†    
 Mut 24 12.4      
 WT 223 15.5      
Signaling pathway   1.15 .61    
 Mut 32 14.4      
 WT 196 14.5      
TP53   2.82 <.001* 2.33 1.41-3.85 .001* 
 Mut 82 9.7      
 WT 165 21.7      
GenotypeNo. of patientsMedian OS, moUnivariable analysisMultivariable analysis
HRPHR95% CIP
Total cohort 247 15      
NGS result   0.46 .02* 1.34 0.54-3.33 .52 
 No mutation 28 24      
 ≥1 mutation 213 14.1      
No. of mutations    .005* 1.22 1.03-1.44 .02* 
TET2   0.89 .67    
 Mut 41 16.1      
 WT 188 14.4      
ASXL1   0.84 .49    
 Mut 47 18.6      
 WT 200 14.4      
TET2-mut/ASXL1-wt and TP53-wt   0.51 .13    
 Present 21 16.1      
 Other 218 14.4      
DNMT3A   1.37 .24    
 Mut 35 11.4      
 WT 193 15.5      
EZH2   2.83 <.001* 2.41 1.03-5.64 .04* 
 Mut 15 9.9      
 WT 232 16.1      
DNA methylation mutation   0.96 .83    
 Mut 79 14.2      
 WT 148 14.4      
Epigenetic regulation mutation   1.04 .82    
 Mut 120 14.2      
 WT 115 15.5      
SF3B1   0.77 .57    
 Mut 13 18.5      
 WT 217 14.4      
Any spliceosome   0.68 .07 1.06 0.58-1.95 .84 
 Mut 77 19.1      
 WT 152 13.1      
RUNX1   1.09 .78†    
 Mut 24 12.4      
 WT 223 15.5      
Signaling pathway   1.15 .61    
 Mut 32 14.4      
 WT 196 14.5      
TP53   2.82 <.001* 2.33 1.41-3.85 .001* 
 Mut 82 9.7      
 WT 165 21.7      

HR, hazard ratio.

*

Denotes statistical significance (P < .05).

†

Associated with a statistically significant (P < .001) impact on OS when stratifying by both RUNX1 and TP53 genotype (see supplemental Figure 2).

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